Disease Markers

Research Article

Neoadjuvant Chemotherapy Followed by Radical Surgery versus Radiotherapy (with or without Chemotherapy) in Patients with Stage IB2, IIA, or IIB Cervical Cancer: A Systematic Review and Meta-Analysis

Table 1

The main characteristics of the five included studies.
StudyYearCountryDesignCase groupControl groupFIGO stageNACTFollow-up (month)Primary endpoints
AgeAgeTherapy
Gupta [16]2018IndiaRCT3165031748CCRTIB2-IIB3 cycles of paclitaxel and carboplatin58.5OS,DFS
Abou-Taleb [17]2016JapanCase control70532277RTIB2-IIB1-3 cycles of irinotecan and nedaplatin&UnclearOS
Yin [18]2011ChinaCase control187439447CCRTIB2-IIB2 or 3 cycles of cisplatin82.8OS,DFS
Chang [19]2000TaiwanRCT68465247RTIB2-IIA3 cycles of VBP scheme#39.0OS,DFS
Sardi [20]1998ArgentinaRCT76447341.5RTIIB3 cycles of VBP scheme84.0OS
Abbreviations: FIGO: International Federation of Gynecology and Obstetrics; NACT: neoadjuvant chemotherapy; RS: radical surgery; CCRT: concurrent chemoradiotherapy; RT: radiotherapy; OS: overall survival; DFS: disease-free survival; mean age. Age values are presented as median; follow-up time is presented as median. &NACT was performed using transuterine arterial chemotherapy (TUAC) or intravenous. #The VBP scheme was used (3 courses of vincristine 1 mg/m2 on day 1, bleomycin 25 mg/m2 on days 1 to 3, and cisplatinum 50 mg/m2 on day 1, at 10-day intervals).