Neoadjuvant Chemotherapy Followed by Radical Surgery versus Radiotherapy (with or without Chemotherapy) in Patients with Stage IB2, IIA, or IIB Cervical Cancer: A Systematic Review and Meta-Analysis

Table 2

The results of pooled HR for OS in different subgroups.

	No.	HR	95% CI		-squared
Country
Asian	4	0.598	0.295-1.212	0.154	79.2%	0.004
Other	1	0.570	0.320-1.014	0.056	—	—
Publication year
Before 2010	2	0.719	0.422-1.227	0.227	27.5%	0.240
After 2010	3	0.488	0.179-1.325	0.159	85.8%	0.001
Sample size
<150	3	0.602	0.332-1.092	0.095	19.7%	0.166
>150	2	0.595	0.179-1.980	0.397	90.6%	0.001
Follow-up time
≤60	2	1.049	0.787-1.397	0.746	0.0%	0.864
>60	2	0.431	0.238-0.781	0.006	45.3%	0.176
Unclear	1	0.280	0.090-0.873	0.028	—	—
Study design
RCT	3	0.877	0.595-1.291	0.505	42.4%	0.176
Case control	2	0.302	0.170-0.538	0.000	0.0%	0.880
Controls therapy
CCRT	2	0.595	0.179-1.980	0.397	90.6%	0.001
RT	3	0.603	0.332-1.092	0.095	44.2%	0.166

Abbreviations: CCRT: concurrent chemoradiotherapy; RT: radiotherapy.