Association between Plasma Sestrin2 Levels and the Presence and Severity of Coronary Artery Disease
Table 1
Clinical characteristics and plasma sestrin2 levels of patients with and without CAD.
CAD(-) ()
value CAD(-) vs. CAD
CAD ()
1-VD ()
2-VD ()
3-VD ()
value among 4 groups
Age (years)
<0.02
<0.05
Gender (male)
77 (60%)
<0.01
131 (75%)
55 (74%)
42 (71%)
35 (81%)
<0.025
BMI (kg/m2)
NS
NS
Hypertension
76 (59%)
<0.001
136 (78%)
55 (75%)
44 (75%)
37 (86%)
<0.005
SBP (mmHg)
<0.02
<0.05
Diabetes mellitus
21 (16%)
<0.001
62 (35%)
19 (26%)
24 (41%)
19 (44%)
<0.001
HbA1c (%)
<0.001
<0.001
Smoking
39 (30%)
NS
67 (38%)
29 (40%)
24 (41%)
14 (33%)
NS
Hyperlipidemia
53 (41%)
<0.01
100 (57%)
41 (56%)
34 (58%)
25 (58%)
NS
Statin
37 (29%)
<0.01
79 (45%)
32 (44%)
26 (44%)
21 (49%)
<0.05
LDL-C (mg/dL)
NS
NS
HDL-C (mg/dL)
<0.001
<0.001
hsCRP (mg/L)
0.43 [0.22, 0.90]
<0.01
0.57 [0.32, 1.41]
0.54 [0.30, 1.04]
0.57 [0.36, 1.32]
0.60 [0.39, 1.85]
<0.02
30 (23%)
NS
55 (31%)
19 (26%)
19 (32%)
17 (40%)
NS
Sestrin2 levels (ng/mL)
14.2 [12.8, 17.9]
<0.05
16.4 [13.0, 20.7]
15.4 [12.9, 18.3]
17.3 [14.5, 22.5]
17.7 [12.1, 22.0]
<0.05
49 (38%)
<0.01
96 (55%)
34 (47%)
39 (66%)
23 (53%)
<0.005
Data represent the or the number (%) of patients, with the exception of hsCRP and sestrin2 levels which are presented as the median value and interquartile range. BMI: body mass index; SBP: systolic blood pressure; LDL-C: low-density lipoprotein cholesterol; HDL-C: high-density lipoprotein cholesterol.
