Association between Plasma Sestrin2 Levels and the Presence and Severity of Coronary Artery Disease

Table 2

Clinical characteristics and plasma sestrin2 levels in the subgroups of patients years and ≥70 years.

CAD(-); ()	CAD(-) vs. CAD	CAD; ()	CAD(-); ()	CAD(-) vs. CAD	CAD; ()
Age (years)		NS			NS
Gender (male)	45 (62%)	<0.025	58 (81%)	32 (57%)	NS	73 (71%)
Hypertension	39 (53%)	<0.01	55 (76%)	37 (66%)	NS	81 (79%)
Diabetes mellitus	13 (18%)	<0.025	27 (38%)	8 (14%)	<0.025	35 (34%)
Smoking	26 (36%)	NS	33 (46%)	13 (23%)	NS	34 (33%)
Hyperlipidemia	29 (40%)	<0.025	43 (60%)	24 (43%)	NS	57 (55%)
Statin	17 (23%)	<0.01	33 (46%)	20 (36%)	<0.01	46 (45%)
LDL-C (mg/dL)		NS			NS
HDL-C (mg/dL)		<0.001			<0.02
hsCRP (mg/L)	0.40 [0.21, 0.94]	<0.05	0.58 [0.30, 1.52]	0.46 [0.26, 0.87]	NS	0.57 [0.32, 1.31]
	18 (25%)	NS	24 (33%)	12 (21%)	NS	31 (30%)
Sestrin2 levels (ng/mL)	13.6 [12.5, 16.8]	<0.05	15.4 [12.8, 20.0]	15.9 [13.6, 22.3]	NS	17.2 [13.3, 21.4]
	21 (29%)	<0.05	34 (47%)	28 (50%)	NS	62 (60%)

Data represent the or the number (%) of patients, with the exception of hsCRP and sestrin2 levels which are presented as the median value and interquartile range.