Diagnostic Accuracy of Holotranscobalamin, Vitamin B12, Methylmalonic Acid, and Homocysteine in Detecting B12 Deficiency in a Large, Mixed Patient Population

Table 5

Diagnostic accuracies of the different markers for detecting potential or probable B12 deficiency (4cB12< -1.5) in men and women over or under 50 years.

Marker ( whole group) ( with 4cB12< -1.5)	Women () ()	Men () ()	<50 years () ()	≥50 years () ()	Women, <50 years () ()	Women, ≥50 years () ()	Men, <50 years () ()	Men, ≥50 years () ()
HoloTC	0.979	0.986	0.977	0.983	0.989	0.978	0.97	0.987
B12	0.954	0.982	0.931	0.974	0.878	0.971	0.996	0.977
MMA	0.972	0.989	0.997	0.973	1	0.957	0.995	0.987
Hcy	0.887^#	0.912^‡	0.756^#	0.916^‡	0.747	0.9^°	0.746	0.936^‡

^‡Significant difference between Hcy and all other markers (). ^#Significant difference between Hcy and HoloTC or MMA (). ^°Significant difference between Hcy and HoloTC or B12 ().