Diagnostic Accuracy of Holotranscobalamin, Vitamin B12, Methylmalonic Acid, and Homocysteine in Detecting B12 Deficiency in a Large, Mixed Patient Population

Table 6

Summary of studies comparing the diagnostic accuracy of HoloTC and B12 to diagnose B12 deficiency.

Author	Year	Number and condition of studied subjects	Definition of B12 deficiency	AUC HoloTC (95% CI)	AUC B12 (95% CI)
Hermann and Obeid [47]	2003	204; 99 healthy subjects and 111 vegetarians	nmol/L	0.88 (n.a.)	0.84 (n.a.)
Hvas and Nexo [48]	2005	806; clinical study participants with creatinine <120 μmol/L	nmol/L and μmol/L	0.90 (0.83, 0.97)	0.85 (0.77, 0.94)
Schrempf et al. [49]	2011	851 neurological patients with normal creatinine (males ≤106 μmol/L; females ≤80 μmol/L)	nmol/L	0.72 (0.65, 0.78)	0.66 (0.51, 0.82)
Herrmann and Obeid [46]	2013	1034 laboratory patient referrals with creatinine <97.2 μmol/L	nmol/L	0.71 (n.a.)	0.63 (n.a.)
Fedosov [25]	2010	865 pooled participants of three different studies		0.928 (n.a.)	0.881 (n.a.)
Valente et al. [43]	2011	700 elderly memory clinic patients	Red cell  pmol/L	0.90 (0.86, 0.93)	0.80 (0.75, 0.85)
Present study	2020	11,833 samples referred to laboratory		0.912 (0.91, 0.92)	0.899 (0.89, 0.91)

CI: confidence interval, n.a.: not available.