Association of Serum Uric Acid Concentration and Its Change with Cardiovascular Death and All-Cause Mortality

Table 1

Characteristics of 325 patients with MHD by serum UA quartiles.

Range of uric acid	Quartile 1	Quartile 2	Quartile 3	Quartile 4	value
	183.759-339.491	339.491-384.933	384.933-438.25	438.25-614.971
	Age (year)						0.026
Male (%)	41 (50.6%)	51 (63.0%)	51 (63.0%)	52 (63.4%)	0.266
Female (%)	40 (49.4%)	30 (37.0%)	30 (37.0%)	30 (36.6%)
Dialysis vintage (months)					0.113
Tunneled cuffed catheter (%)	29 (35.8%)	27 (33.3%)	19 (23.5%)	14 (17.1%)	0.025
AvF (%)	52 (64.2%)	54 (66.7%)	62 (76.5%)	68 (82.9%)
Hypertension (%)	80 (98.8%)	80 (98.8%)	80 (98.8%)	82 (100%)	0.796
Mean hemoglobin (g/L)					0.678
Mean phosphorus (mmol/L)					<0.001
Mean calcium (mmol/L)					0.675
Mean PTH (μg/L)					<0.001
Mean albumin (g/L)					0.397
Mean serum uric acid (μmol/L)					<0.001
Uric acid variability (%)					<0.001
Primary renal disease ()					<0.001
Hypertensive kidney lesion	1 (1.2%)	8 (9.9%)	8 (9.9%)	9 (11.0%)
ANCA	1 (1.2%)	0 (0.0%)	2 (2.5%)	0 (0.0%)
Diabetes	57 (70.4%)	40 (49.4%)	30 (37.0%)	20 (24.4%)
Glomerulonephritis	17 (21.0%)	24 (29.6%)	31 (38.3%)	45 (54.9%)
Drug-induced kidney damage	1 (1.2%)	0 (0.0%)	1 (1.2%)	1 (1.2%)
Polycystic kidney	2 (2.5%)	4 (4.9%)	2 (2.5%)	3 (3.7%)
Renal allograft dysfunction	1 (1.2%)	1 (1.2%)	2 (2.5%)	2 (2.4%)
Lupus nephritis	0 (0.0%)	0 (0.0%)	1 (1.2%)	1 (1.2%)
Obstructive nephropathy	1 (1.2%)	4 (4.9%)	4 (4.9%)	1 (1.2%)
Outcome
All-cause death	45 (55.6%)	29 (35.8%)	23 (28.4%)	19 (23.2%)	<0.001
Cardiac death	25 (30.9%)	12 (14.8%)	10 (12.3%)	11 (13.4%)	0.005

AvF = arteriovenous fistula; PTH = parathyroid hormone;  = number; ANCA = antineutrophil cytoplasmic antibodies; MHD = maintenance hemodialysis; UA = uric acid.