Association of Serum Uric Acid Concentration and Its Change with Cardiovascular Death and All-Cause Mortality
Table 4
Cox regression analysis of all-cause mortality and cardiac death.
Variable
Univariable
Multivariable
HR (95% CI)
value
HR (95% CI)
value
Cox regression analysis of all-cause mortality
Age (years)
1.058 (1.042-1.074)
<0.001
1.044 (1.026-1.062)
<0.001
Diabetes (,)
2.154 (1.477-3.14)
<0.001
1.751 (1.138-2.696)
0.011
Vascular access (,)
0.406 (0.274-0.602)
<0.001
0.759 (0.484-1.189)
0.228
Albumin (g/L)
0.819 (0.776-0.865)
<0.001
0.899 (0.842-0.96)
0.001
Mean uric acid (μmol/L)
0.995 (0.992-0.997)
<0.001
0.996 (0.992-1.000)
0.035
1.0 (1.0-1.0)
0.042
1.0 (1.0-1.0)
0.223
Cox regression analysis of cardiac death
Age (years)
1.073 (1.049-1.098)
<0.001
1.066 (1.037-1.096)
<0.001
Diabetes (,)
3.157 (1.788-5.572)
<0.001
3.114 (1.577-6.150)
0.001
Vascular access (,)
0.322 (0.187-0.554)
<0.001
0.605 (0.324-1.130)
0.115
Albumin (g/L)
0.835 (0.77-0.905)
<0.001
0.957 (0.869-1.054)
0.369
Mean uric acid (μmol/L)
0.994 (0.99-0.998)
0.001
0.994 (0.988-1.0)
0.056
1.0 (1.0-1.0)
0.146
1.0 (1.0-1.0)
0.098
HR (hazard ratio) indicates the relative increased risk of all-cause or cardiac death with each change in age, mean uric acid, uric acid variability, albumin, diabetes positive, or vascular access. reflected the interaction between uric acid and its variability. In multivariable regression analysis, these six variables were included in the same model.
