The Combination of CD147 and MMP-9 Serum Levels Is Identified as Novel Chemotherapy Response Markers of Advanced Non-Small-Cell Lung Cancer

Figure 2

(a) Compared with baseline, serum concentrations of CD147 increased gradually after the first and second chemotherapy cycles and then decreased after the fourth cycle in patients with NSCLC. (b) Association between the changes in serum concentrations of CD147 from baseline to the first chemotherapy cycle and tumor response after the first chemotherapy cycle. (c) Association between the variation in serum concentrations of CD147 from the first to second chemotherapy cycle and tumor response after the second chemotherapy cycle. (d) Association between the alterations in serum concentrations of CD147 from the second to fourth chemotherapy cycle and tumor response evaluated after the fourth chemotherapy cycle. Each dot represents a patient, and red lines represent median values. CR: complete response; PR: partial response; SD: stable disease; PD: progressive disease. and .

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