CTLA-4 +49A/G Polymorphism Increases the Susceptibility to Bladder Cancer in Chinese Han Participants: A Case-Control Study

Table 3

Stratified analyses between CTLA-4 +49A/G polymorphism and the risk of bladder cancer.

Variable	Case/control			AG vs. AA OR (95% CI);	GG vs. AA OR (95% CI);	GG vs. OR (95% CI);	vs. AA OR (95% CI);
	AA	AG	GG
Sex
Male	178/239	107/111	17/12	1.29 (0.93-1.80); 0.124	1.90 (0.89-4.08); 0.099	1.74 (0.82-3.70); 0.151	1.35 (0.99-1.86); 0.060
Female	28/49	20/21	4/2	1.67 (0.77-3.60); 0.193	3.50 (0.60-20.34); 0.301	2.92 (0.51-16.56); 0.404	1.83 (0.87-3.82); 0.109
Smoking
Yes	136/122	99/49	15/8	1.81 (1.19-2.76); 0.006	1.68 (0.69-4.11); 0.253	1.36 (0.57-3.29); 0.489	1.79 (1.20-2.68); 0.004
No	70/166	28/83	6/6	0.80 (0.48-1.33); 0.392	2.37 (0.74-7.60); 0.147	2.54 (0.80-8.07); 0.102	0.91 (0.56-1.47); 0.689
Drinking
Yes	130/110	84/58	18/5	1.23 (0.81-1.87); 0.343	3.05 (1.10-8.47); 0.033	2.83 (1.03-7.77); 0.044	1.37 (0.92-2.05); 0.127
No	76/178	43/74	3/9	1.36 (0.86-2.16); 0.191	0.78 (0.21-2.96); 0.967	0.71 (0.19-2.66); 0.839	1.30 (0.83-2.03); 0.256
Age (years)
<60	87/126	54/53	13/9	1.48 (0.93-2.35); 0.103	2.09 (0.86-5.11); 0.105	1.83 (0.76-4.41); 0.176	1.57 (1.01-2.43); 0.046
≥60	119/162	73/79	8/5	1.26 (0.85-1.87); 0.257	2.18 (0.70-6.83); 0.182	2.01 (0.65-6.24); 0.228	1.31 (0.89-1.93); 0.167

Bold values are statistically significant ().