A 17-Gene Signature Predicted Prognosis in Renal Cell Carcinoma
Table 1
The expression differences of the 17 genes in TCGA dataset with SurvExpress.
Gene
Gene ID
Full name
Function
HR (95% CI)
value
P3H1
64175
Prolyl 3-hydroxylase 1
Has prolyl 3-hydroxylase activity and growth suppressive activity in fibroblasts and involve in the secretory pathway of cells
2.96 (2.09-4.18)
9.25-10
JAK3
3718
Janus kinase 3
Nonreceptor tyrosine kinase involved in various processes such as cell growth, development, or differentiation. Mediate essential signaling in both innate and adaptive immunity and hematopoiesis during T cell development.
3.04 (2.13-4.33)
8.521-10
PTTG1
9232
Pituitary tumor-transforming 1
Regulatory protein which plays a central role in chromosome stability, the p53/TP53 pathway, and DNA repair
3.07 (2.15-4.4)
7.852-10
B3GNTL1
146712
BetaGal beta-1,3-N-acetylglucosaminyltransferase like 1
Putative glycosyltransferase.
3.02 (2.12-4.29)
7.533-10
ARPC3
10094
Actin-related protein 2/3 complex subunit 3
Localize to the lamellipodia of stationary and locomote fibroblasts, inducing actin polymerization and potentially participating in lamellipodial protrusion
3.08 (2.15-4.41)
7-10
SLC27A2
26458
Solute carrier family 27 (fatty acid transporter), member 2
Acyl-CoA synthetase probably involves in bile acid metabolism. May have additional roles in fatty acid metabolism and be involved in translocation of long-chain fatty acids across membranes
3.01 (2.12-4.28)
6.999-10
PHOSPHO2
73373
Phosphatase, orphan 2
High activity toward pyridoxal 5-phosphate. Also active at a much lower level toward phosphoethanolamine, pyrophosphate, phosphocholine, phospho-l-tyrosine, fructose-6-phosphate, p-nitrophenyl phosphate, and h-glycerophosphate.
3.01 (2.12-4.27)
6.661-10
SKA1
220134
Spindle- and kinetochore-associated complex subunit 1
Component of the SKA1 complex that is essential for proper chromosome segregation. High expression levels of SKA1 were significantly associated with low DFS.
3.09 (2.16-4.41)
5.455-10
TMEM232
642987
Transmembrane protein 232
Unclear.
3.00 (2.12-4.23)
4.299-10
SOWAHB
345079
Sosondowah ankyrin repeat domain family member B
Unclear.
3.10 (2.17-4.42)
4.173-10
CCDC121
403180
Coiled-coil domain-containing 121
Unclear.
3.14 (2-4.47)
2.512-10
MARS
4141
Methionyl-tRNA synthetase
A protein-coding gene plays a role in the synthesis of ribosomal RNA in the nucleolus.
3.09 (2.18-4.37)
1.969-10
ADH5
128
Alcohol dehydrogenase 5 (class III), chi polypeptide
Catalyze the oxidation of long-chain primary alcohols and the oxidation of S-(hydroxymethyl) glutathione. Also oxidize long-chain omega-hydroxy fatty acids.
3.19 (2.24-4.56)
1.649-10
DVL3
1857
Dishevelled segment polarity protein 3
Involve in the signal transduction pathway mediated by multiple Wnt genes.
3.17 (2.23-4.49)
9.754-11
CDC14B
8555
Cell division cycle 14B
Dual-specificity phosphatase involved in DNA damage response. Essential regulator of the G2 DNA damage checkpoint, a key activator of the anaphase-promoting complex/cyclosome (APC/C).
3.32 (2.32-4.74)
5.069-11
FBXO3
26273
F-box protein 3
Substrate recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Mediate the ubiquitination of HIPK2 and probably that of EP300, leading to rapid degradation by the proteasome.
3.32 (2.32-4.74)
4.352-11
CARS
833
Cysteinyl-tRNA synthetase
An important tumor-suppressor gene. Alterations in this region is associated with Beckwith-Wiedemann syndrome; Wilms tumor; adrenocortical carcinoma; and lung, ovarian, and breast cancers, rhabdomyosarcoma.
