Predicting Liver Disease Risk Using a Combination of Common Clinical Markers: A Screening Model from Routine Health Check-Up

Table 1

Baseline characteristics of AILD cases and healthy controls.

Features	All patients ()	HC ()	Statistic value	value
Gender(female/male)	501/80	397/385	143.09	<0.001
Age, y (range)	59 (16-88)	51 (38-60)	9.47	<0.001
Biochemical parameters
TP (g/L)	76 (69-82)	74 (71-77)	3.01	0.003
ALB (g/L)	39 (34-43)	47 (45-48)	17.57	<0.001
GLB (g/L)	37 (32-42)	28 (25-30)	18.33	<0.001
ALT (IU/L)	73 (41-159)	17 (12-24)	20.69	<0.001
AST (IU/L)	76.9 (47-145)	18 (16-22)	23.02	<0.001
ALP (IU/L)	179 (115-328)	62 (52-74)	22.09	<0.001
GGT (IU/L)	191 (98-370)	21 (15-29)	21.92	<0.001
TBIL (μmol/L)	19.6 (12.8-42.5)	10.9 (8.3-14.0)	14.50	<0.001
DBIL (μmol/L)	7.6 (4.4-22.33)	4.0 (3.3-4.9)	13.46	<0.001
LN (%)	226 (38.9)	26 (3.3)	195.00	<0.001
CEAID (%)	257 (44.2)	39 (5.0)	167.19	<0.001
FA (%)	50 (8.6)	15 (1.9)	205.38	<0.001

Statistic value are calculated with the Chi-square test(χ²) in categorical variables and Mann-Whitney test in numerical variables. Abbreviations: TP: total protein; ALB: albumin; GLB: globulin; ALT: alanine aminotransferase; AST: aspartate aminotransferase; ALP: alkaline phosphatase; GGT: gamma-glutamyl transpeptidase; TBIL: total bilirubin; DBIL: direct bilirubin; LN: abdominal lymph node enlargement (B-mode ultrasound); CEAID: current extrahepatic autoimmune diseases; FA: familial autoimmunity.