Predicting Liver Disease Risk Using a Combination of Common Clinical Markers: A Screening Model from Routine Health Check-Up

Table 3

Logistic regression models with predictive variables measured by routine health check-up.

	Log OR (β)	SE (β)	value	OR (exp[β])	95% CI OR
Model 1
Gender (male as reference)	1.74	0.46	<0.001	5.69	2.29–14.12
Age at diagnosis (years)	0.09	0.02	<0.001	1.10	1.07–1.13
GLB (g/L)	0.25	0.04	<0.001	1.28	1.19–1.38
ALT (IU/L)	0.04	0.01	<0.001	1.04	1.03–1.06
GGT (IU/L)	0.01	0.002	<0.001	1.01	1.006–1.014
LN	2.18	0.60	<0.001	8.85	2.73–28.69
CEAID	1.26	0.47	0.007	3.51	1.41–8.76
FA	1.92	0.53	<0.001	6.85	2.41–19.49
Model 2
Gender (male as reference)	1.53	0.33	<0.001	4.64	2.44–8.82
Age at diagnosis (years)	0.07	0.01	<0.001	1.07	1.05–1.10
GLB (g/L)	0.28	0.03	<0.001	1.32	1.26–1.39
LN	2.85	0.45	<0.001	17.24	7.18–41.41
CEAID	1.55	0.34	<0.001	4.72	2.41–9.23
FA	1.86	0.41	<0.001	6.41	2.84–14.44

Notes: Model 1 (M1) used the eight common variables after correlation analyses, and Model 2 (M2) used variables without liver- or cholangetic injury markers. Abbreviations: AILD: autoimmune liver disease; GLB: globulin; ALT: alanine aminotransferase; GGT: γ-glutamyltransferase; LN: abdominal lymph node. Enlargement (B-mode ultrasound); CEAID: current extrahepatic autoimmune diseases; FA: familial autoimmunity.