Peripheral Blood Occludin Level as a Biomarker for Perioperative Cerebral Edema in Patients with Brain Tumors

Figure 4

The relationship between the postoperative serum occludin level and the pericavity brain edema after surgery. (a) Pearson’s correlation analysis indicating that the postoperative serum occludin level was significantly positively correlated with the extent of the postoperative pericavity edema as measured by the vertical distance from the outer edge of the maximal edema zone to the cavity boundary (). (b) Postoperative serum occludin levels for the various Steinhoff grades of pericavity edema. Data are presented as (grade 0, ; grade I, ; grade II, ; and grade III, ). vs. grade 0; ^# vs. grade I; and ^$ versus grade II. (c) Pearson’s correlation analysis indicating that the postoperative serum occludin level was not significantly correlated with the tumor diameter. (d) Receiver operating characteristic curve for the ability of the postoperative serum occludin level to distinguish between mild and severe pericavity edema. AUC: area under the curve; CI: confidence interval.

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