Serum Clusterin: A Potential Marker for Assessing the Clinical Severity and Short-Term Prognosis of Hepatitis B Virus-Related Acute-on-Chronic Liver Failure
Table 5
Univariate analysis of baseline clinical variables for hepatitis B virus-related acute-on-chronic liver failure survival and nonsurvival.
Characteristics
Survival ()
Nonsurvival ()
value
Age (years)
0.002
Male (%),
87.78% (62)
67.65% (23)
0.622
Alanine aminotransferase (U/L)
384.25 (85.70, 1863.20)
339.25 (29.70, 1834.40)
0.432
Aspartate aminotransferase (U/L)
391.15 (87.80, 1191.40)
332.30 (33.40, 1520.70)
0.718
Total bilirubin (mg/dL)
0.011
Albumin (g/L)
31.35 (22.00, 446.10)
30.45 (17.30, 248.00)
0.184
Serum creatinine (mg/dL)
0.70 (0.43, 1.64)
0.72 (0.37, 2.23)
0.794
Prothrombin activity (%)
<0.001
International normalized ratio
<0.001
Hepatitis B virus DNA (log IU/mL)
0.352
White blood cell (×109/L)
0.538
Neutrophil count (×109/L)
3.63 (0.81, 13.69)
4.09 (0.85, 72.31)
0.150
Lymphocyte count (×109/L)
1.31 (0.31, 4.05)
1.00 (0.29, 18.22)
0.126
Neutrophil-lymphocyte ratio
0.029
Platelet count (×109/L)
0.112
MELD score
0.001
Clusterin (μg/mL)
62.78 (12.17, 231.86)
34.80 (12.62, 92.49)
<0.001
Spontaneous bacterial peritonitis, (%)
19 (25.68%)
12 (35.29%)
0.067
Hepatic encephalopathy, (%)
13 (17.57%)
16 (47.06%)
0.010
Hepatorenal syndrome, (%)
3 (4.05%)
6 (17.65%)
0.011
Data are presented as (%), , or median (minimum, maximum). values in bold numerals indicate significant values. Abbreviations: MELD score: model for end-stage liver disease score.
