Noncoding RNAs in Nonalcoholic Fatty Liver Disease: Potential Diagnosis and Prognosis Biomarkers

Table 3

Confirmed lncRNAs in NAFLD.

Name of lncRNA	Type of lncRNA	Chromosome	Expression	Stage	Gene targets	References
MEG3	Intergenic	14q32	Downregulated in human hepatic	NAFLD/NASH; Activated HSCs	DNMT and TGFB1	[72, 73]
MALAT-1	Intergenic	11q13.1	Upregulated; Identified in animal models; MALAT1 knockdown leads to downregulation of CXCL5; Plays a key role in tumor cell proliferation, migration, and invasion	Fibrosis	CXCL5	[132]
HOTAIR	Antisense	12q13.13	Upregulated/replicated in human	HCC	PTEN	[133]
APTR	Intergenic	7q21	Upregulated/involved in regulating cell cycle progression and cell proliferation in liver cirrhosis	HCC	TGF-β1	[134]
PVT1	Intergenic	8q24.21	Upregulated/not replicate in human	HCC	miR-152	[135]
lnRNA-CoX2	Antisense	1p33	Upregulated	Liver fibrosis; HCC	PTGS2	[80, 81],
NEAT1	Intergenic	11q13.1	Upregulated	NAFLD/NASH; Activated HSCs	ACTA2 and Col1a1	[83]