Research Article
Coexpression of Matrix Metalloproteinase-7 and Tissue Inhibitor of Metalloproteinase-1 as a Prognostic Biomarker in Gastric Cancer
Table 1
Clinicopathological characteristics of 285 patients and immunohistochemical staining for MMP-7 and TIMP-1.
| | Variables | (%) | MMP-7 | TIMP-1 | | + (%) | | + (%) | |
| | Sex | | | | 0.02 | | 0.06 | | Male | 219 (76.8) | 83 (37.9) | | 54 (24.7) | | | Female | 66 (23.2) | 15 (22.7) | | 24 (36.4) | |
| | Age | | | | 0.55 | | 0.37 | | <70 | 212 (74.4) | 75 (35.4) | | 61 (28.8) | | | ≥70 | 73 (25.6) | 23 (31.5) | | 17 (23.3) | |
| | T stage | | | | 0.71 | | 0.67 | | T1 | 4 (1.4) | 1 (25.0) | | 1 (25.0) | | | T2 | 10 (3.5) | 2 (20.0) | | 1 (10.0) | | | T3 | 148 (51.9) | 49 (33.1) | | 40 (27.0) | | | T4 | 123 (43.2) | 46 (37.4) | | 36 (29.3) | |
| | N stage | | | | 0.03 | | 0.67 | | N0 | 47 (16.5) | 8 (17.0) | | 11 (23.4) | | | N1 | 48 (16.8) | 16 (33.3) | | 13 (27.1) | | | N2 | 77 (27) | 33 (42.9) | | 25 (32.5) | | | N3 | 113 (39.6) | 41 (36.3) | | 29 (25.7) | |
| | Differentiation | | | | 0.74 | | 0.48 | | Middle | 58 (20.4) | 21 (36.2) | | 18 (31.0) | | | Low | 227 (79.6) | 77 (33.9) | | 60 (26.4) | |
| | Type | | | | 0.59 | | 0.73 | | Adenocarcinoma and others | 255 (89.5) | 89 (34.9) | | 69 (27.4) | | | Signet-ring cell | 30 (10.5) | 9 (30.0) | | 9 (30.0) | |
| | Size | | | | 0.30 | | 0.61 | | <5 cm | 85 (29.8) | 33 (38.8) | | 25 (29.4) | | | ≥5 cm | 200 (70.2) | 65 (32.5) | | 53 (26.5) | |
| | Lymph vascular invasion | | | | 0.76 | | 0.63 | | No | 64 (22.5) | 21 (32.8) | | 16 (25.0) | | | Yes | 221 (77.5) | 77 (34.8) | | 62 (28.1) | |
| | Neural invasion | | | | 0.002 | | 0.11 | | No | 78 (27.4) | 16 (20.5) | | 16 (20.5) | | | Yes | 207 (72.6) | 82 (39.6) | | 62 (30.0) | |
| | Chemotherapy | | | | 0.13 | | 0.07 | | No | 160 (56.1) | 61 (38.1) | | 37 (23.1) | | | Yes | 125 (43.9) | 37 (29.6) | | 41 (32.8) | |
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+: positive expression.
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