In Search of TGCT Biomarkers: A Comprehensive In Silico and Histopathological Analysis

Figure 13

Suggested diagnostic panel for the detection of the testicular tumor (TT) and testicular germ cell tumor (TGCT) and the diagnosis of seminoma (SE), nonseminoma (NS), germ cell neoplasia in situ (GCNIS), and nonseminoma (NS) components. Legend is color-coded for the type of analysis done. The asterisk denotes possible issues with a diagnosis between methods placed because of no information being available for individual NS components, which are known to be very heterogeneous. A complete diagnosis of NS components is not possible without analysis of gene expression on the protein level.