In Search of TGCT Biomarkers: A Comprehensive In Silico and Histopathological Analysis

Table 1

Diagnostic positivity for the selected genes. Depiction of percentage of samples declared diagnostically positive or negative for the investigated components (HT, TGCT, GCNIS, SE, NS, EC, TE, YST, and CH) per gene of interest. Samples with IRS 0-3 were considered diagnostically positive.

Gene	Samples	HT	GCNIS	TGCT	SE	NS	EC	TE	YSC	CH
OCT4	Total	48	59	156	47	109	41	29	27	12
	Positive	0 (0%)	44 (75%)	64 (41%)	32 (68%)	32 (29%)	30 (73%)	0 (0%)	0 (0%)	0 (0%)
HOXA9	Total	41	60	140	48	92	36	25	24	7
	Positive	35 (85%)	48 (80%)	89 (64%)	14 (29%)	75 (82%)	30 (83%)	22 (88%)	17 (71%)	6 (86%)
SOX2	Total	35	58	154	48	106	40	29	26	11
	Positive	0 (0%)	0 (0%)	18 (12%)	0 (0%)	18 (17%)	17 (43%)	0 (0%)	1 (4%)	0 (0%)
RASSF1	Total	41	64	158	49	109	41	29	27	12
	Positive	2 (5%)	33 (52%)	9 (6%)	3 (6%)	6 (6%)	1 (2%)	3 (10%)	1 (4%)	1 (8%)
C-KIT	Total	45	59	154	48	106	40	29	25	12
	Positive	0 (0%)	43 (73%)	38 (25%)	38 (79%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)
MGMT	Total	45	53	150	48	102	39	27	26	10
	Positive	41 (91%)	16 (30%)	17 (11%)	7 (15%)	10 (10%)	3 (8%)	4 (15%)	3 (12%)	0 (0%)
SALL4	Total	35	60	143	49	94	36	25	25	8
	Positive	1 (3%)	49 (82%)	109 (76%)	48 (98%)	61 (65%)	32 (89%)	3 (12%)	24 (96%)	2 (25%)
CFC1	Total	37	62	151	48	103	40	27	25	11
	Positive	1 (3%)	2 (3%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)
SOX17	Total	43	60	156	48	108	41	29	26	12
	Positive	0 (0%)	33 (55%)	23 (15%)	22 (46%)	1 (1%)	1 (2%)	0 (0%)	0 (0%)	0 (0%)
PRSS21	Total	47	71	156	47	109	41	29	27	12
	Positive	1 (2%)	44 (62%)	8 (5%)	2 (4%)	6 (6%)	0 (0%)	2	0 (0%)	4 (33%)
NANOG	Total	41	57	157	48	109	41	29	27	12
	Positive	0 (0%)	34 (60%)	66 (42%)	41 (85%)	25 (23%)	21 (51%)	0 (0%)	4 (15%)	0 (0%)
MAGEC2	Total	36	65	156	48	108	41	29	26	12
	Positive	21 (58%)	14 (22%)	7 (4%)	7 (15%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	(0%)