Prognostic Value of Microvessel Density in Head and Neck Squamous Cell Carcinoma: A Meta-Analysis

Table 2

Meta-analyses of MVD and survival of HNSCC.

	N of studies	Model	HR (95% CI)	Log rank	Heterogeneity (, )
Total OS	11	Random	1.663 (1.236, 2.237)	0.001	77.1%, <0.001
Total PFS	7	Random	2.069 (1.281, 3.343)	0.003	78.4%, <0.001
European OS	5	Random	1.979 (1.174, 3.334)	0.010	85.7%, <0.001
North American OS	3	Fixed	1.049 (0.805, 1.367)	0.725	13.9%, 0.313
Asian OS	3	Fixed	2.530 (1.534, 4.174)	<0.001	20.6%, 0.284
Median/mean age ≥ 60 OS	5	Random	2.238 (1.213, 4.130)	0.010	67.3%, 0.016
Median/mean age ≥60 PFS	5	Random	2.728 (1.492, 4.986)	0.001	68.2%, 0.014
Pharynx OS	4	Random	1.390 (0.993, 1.945)	0.055	73.8%, 0.010
Oral cavity OS	2	Random	2.748 (1.053, 7.170)	0.039	54.1%, 0.140
CD105 OS	4	Fixed	2.916 (1.945, 4.370)	<0.001	32.2%, 0.219
Surgery OS	7	Random	2.578 (1.522, 4.365)	<0.001	61.5%, 0.016
Chemo-radiotherapy OS	4	Random	1.176 (0.917, 1.508)	0.202	67.2%, 0.027

HR: hazard ratio; CI: confidence interval; OS: overall survival; PFS: progression-free survival; N: number.