Serum Amyloid A Is a Biomarker of Disease Activity and Health-Related Quality-of-Life in Patients with Antineutrophil Cytoplasmic Antibody-Associated Vasculitis

Table 1

Clinical and laboratory data of the 75 patients.

	Values
Variants ( (%))
MPA	38 (50.7%)
GPA	21 (28.0%)
EGPA	16 (21.3%)
Demographic data
Age (years)
Male gender ( (%))	26 (34.7%)
Disease duration (months)
AAV-specific indices
BVAS
FFS (2009)
VDI
SF-36 PCS score
SF-36 MCS score
Clinical manifestations ( (%))
General	26 (34.7%)
Cutaneous	9 (12.0%)
Mucous membrane and eye	5 (6.7%)
Ear, nose, and throat	35 (46.7%)
Pulmonary	48 (64.0%)
Cardiovascular	5 (6.7%)
Abdominal	0 (0.0%)
Renal	38 (50.7%)
Nervous system	16 (21.3%)
ANCA positivity ( (%))
P-ANCA	41 (54.7%)
C-ANCA	7 (9.3%)
MPO-ANCA	37 (49.3%)
PR3-ANCA	6 (8.0%)
ANCA positivity	49 (65.3%)
Laboratory data
WBC count (/mm^3)
Hemoglobin (g/dL)
Platelet count (×1000/mm^3)
Blood urea nitrogen (mg/dL)
Creatinine (mg/dL)
Total protein (g/dL)
Serum albumin (g/dL)
AST (IU/L)
ALT (IU/L)
ESR (mm/hr)
CRP (mg/L)
SAA (ng/mL)

Values are expressed as or number (percentage). MPA: microscopic polyangiitis; GPA: granulomatosis with polyangiitis; EGPA: eosinophilic granulomatosis with polyangiitis; AAV: ANCA-associated vasculitis; ANCA: antineutrophil cytoplasmic antibody; BVAS: Birmingham Vasculitis Activity Score; FFS: five-factor score; VDI: vasculitis damage index; SF-36: Short-Form 36-Item Health Survey; PCS: physical component summary; MCS: mental component summary; P: perinuclear; C: cytoplasmic; MPO: myeloperoxidase; PR3: proteinase 3; WBC: white blood cell; AST: aspartate aminotransferase; ALT: alanine aminotransferase; ESR: erythrocyte sedimentation rate; CRP: C-reactive protein; SAA: serum amyloid A.