Serum Amyloid A Is a Biomarker of Disease Activity and Health-Related Quality-of-Life in Patients with Antineutrophil Cytoplasmic Antibody-Associated Vasculitis
Table 3
Comparison of clinical and laboratory features according to BVAS.
Patients with low BVAS ()
Patients with high BVAS ()
value
Variants ( (%))
0.264
MPA
16 (43.2%)
22 (57.9%)
GPA
12 (32.4%)
9 (23.7%)
EGPA
9 (24.3%)
7 (18.4%)
Demographic data
Age (years)
0.644
Male gender ( (%))
11 (29.7%)
15 (39.5%)
0.379
Disease duration (months)
0.002
AAV-specific indices
BVAS
<0.001
FFS (2009)
0.221
VDI
0.263
SF-36 PCS score
0.005
SF-36 MCS score
0.048
Clinical manifestations ( (%))
General
6 (16.2%)
20 (52.6%)
0.001
Cutaneous
3 (8.1%)
6 (15.8%)
0.480
Mucous membrane and eye
1 (2.7%)
4 (10.5%)
0.358
Ear, nose, and throat
16 (43.2%)
19 (50.0%)
0.560
Pulmonary
19 (51.4%)
29 (76.3%)
0.025
Cardiovascular
2 (5.4%)
3 (7.9%)
0.999
Abdominal
0 (0.0%)
0 (0.0%)
N/A
Renal
13 (35.1%)
25 (65.8%)
0.008
Nervous system
8 (21.6%)
8 (21.1%)
0.952
ANCA positivity ( (%))
P-ANCA
16 (43.2%)
25 (65.8%)
0.051
C-ANCA
2 (5.4%)
5 (13.2%)
0.430
MPO-ANCA
13 (35.1%)
24 (63.2%)
0.016
PR3-ANCA
1 (2.7%)
5 (13.2%)
0.200
ANCA positivity
19 (51.4%)
30 (78.9%)
0.013
Laboratory data
WBC count (/mm3)
0.004
Hemoglobin (g/dL)
<0.001
Platelet count (×1000/mm3)
0.004
Blood urea nitrogen (mg/dL)
0.006
Creatinine (mg/dL)
0.008
Total protein (g/dL)
0.004
Serum albumin (g/dL)
<0.001
AST (IU/L)
0.609
ALT (IU/L)
0.578
ESR (mm/hr)
<0.001
CRP (mg/L)
<0.001
SAA (ng/mL)
<0.001
Values are expressed as or number (percentage). BVAS: Birmingham Vasculitis Activity Score; MPA: microscopic polyangiitis; GPA: granulomatosis with polyangiitis; EGPA: eosinophilic granulomatosis with polyangiitis; AAV: ANCA-associated vasculitis; ANCA: antineutrophil cytoplasmic antibody; FFS: five-factor score; VDI: vasculitis damage index; SF-36: Short-Form 36-Item Health Survey; PCS: physical component summary; MCS: mental component summary; N/A: not applicable; P: perinuclear; C: cytoplasmic; MPO: myeloperoxidase; PR3: proteinase 3; WBC: white blood cell; AST: aspartate aminotransferase; ALT: alanine aminotransferase; ESR: erythrocyte sedimentation rate; CRP: C-reactive protein; SAA: serum amyloid A.
