Pharmacogenomics Study for Raloxifene in Postmenopausal Female with Osteoporosis
Table 1
Top 10 significant genes of gene-based analysis at the lumbar spine site.
Gene
CHR
START
STOP
Number of SNPs
ZSTAT
value
KO mouse bone phenotype
FUT9
6
96463860
96663488
474
4.11
NA
APBB1IP
10
26727132
26856732
304
3.962
NA
MYO15B
17
73584139
73622929
104
3.808
NA
USHBP1
19
17359985
17393595
54
3.728
Vertebral fusion
DNAH5
5
13690440
13944652
691
3.712
No
NRG2
5
139226364
139422884
238
3.709
NA
KIAA0196
8
126036502
126104082
211
3.691
NA
PHYH
10
13319796
13344412
70
3.625
No
ELTD1
1
79355449
79472403
309
3.567
NA
OR4K1
14
20403767
20404842
7
3.545
NA
CHR: chromosome; START: start position of the gene; STOP: stop position of the gene. Knockout mouse bone-related phenotypes were queried from International Mouse Phenotype Consortium.
