Pharmacogenomics Study for Raloxifene in Postmenopausal Female with Osteoporosis
Table 2
Top 10 significant genes of gene-based analysis at the femoral neck site.
Gene
CHR
START
STOP
Number of SNPs
ZSTAT
value
KO mouse bone phenotype
AC068987.1
12
52203789
52206636
1
3.953
NA
GHRHR
7
30978284
31032869
139
3.859
BMD decrease
F10
13
113777128
113803843
35
3.836
NA
SCN8A
12
51984050
52206648
200
3.674
NA
TMEM128
4
4237269
4249950
84
3.562
NA
MRPL34
19
17403418
17417652
35
3.51
NA
HSPA9
5
137890571
137911133
14
3.501
NA
ABHD8
19
17402940
17421045
42
3.494
BMD decrease
ABLIM2
4
7967039
8160559
488
3.394
NA
TMPRSS6
22
37461476
37505603
97
3.38
BMD decrease
CHR: chromosome; START: start position of the gene; STOP: stop position of the gene. Knockout mouse bone-related phenotypes were queried from International Mouse Phenotype Consortium.
