Pharmacogenomics Study for Raloxifene in Postmenopausal Female with Osteoporosis

Table 3

Gene-set analysis of raloxifene response at lumbar spine site.

Database	Pathway	Number of genes	Beta	SE	value	value
GO bp	Iron ion homeostasis	63	0.363	0.101		0.884
GO bp	Regulation of immunoglobulin secretion	14	0.774	0.227		0.884
GO bp	Transition metal ion homeostasis	96	0.267	0.08		0.884
Curated gene sets	Inhibition of replication initiation of damaged DNA by rb1 e2f1	10	0.879	0.266		0.884
Curated gene sets	Apoptosis	82	0.28	0.086		0.884
GO bp	Response to protozoan	20	0.569	0.177		0.884
Curated gene sets	Cdh1 targets 3 dn	58	0.331	0.106		0.884
Curated gene sets	Treating iron overload	7	0.879	0.283		0.884
GO bp	Toll like receptor signaling pathway	77	0.3	0.099		0.884
GO bp	Cellular iron ion homeostasis	40	0.374	0.124		0.884
Curated gene sets	Tlx targets 60 hr dn	258	0.148	0.049		0.884
GO bp	Negative regulation of platelet activation	17	0.626	0.211		0.884
Curated gene sets	Tgfb1 signaling via nfic 10 hr dn	29	0.464	0.158		0.884
Curated gene sets	Response to tosedostat 24 hr dn	936	0.074	0.025		0.884
Curated gene sets	Metabolism of amino acids and derivatives	186	0.166	0.057		0.884
GO bp	Cellular defense response	54	0.323	0.111		0.884
Curated gene sets	Akt phosphorylates targets in the cytosol	12	0.559	0.193		0.884
Curated gene sets	Asbcell pathway	9	0.783	0.271		0.884
Curated gene sets	Cell cycle s	152	0.193	0.068		0.884
Curated gene sets	Ar tf pathway	47	0.352	0.124		0.884

GO: gene ontology; bp: biological process; values were from false discovery rate.