Responsive Expression of MafF to β-Amyloid-Induced Oxidative Stress

Figure 4

MafF expression participated in the oxidative stress caused by Aβ. The protein expressions of GCLC in the (a) hippocampus from APP/PS1 mice and in the (c) hippocampus from SD rats after Aβ injection and in (e) SH-SY5Y cells treated with Aβ (20 μM, 48 h). The GSH levels in the (b) hippocampus from APP/PS1 mice and in the (d) hippocampus from SD rats after Aβ injection and in (f) SH-SY5Y cells treated with Aβ (20 μM, 48 h). The protein expressions of MafF, MafG, and MafK in SH-SY5Y cells transfected with MafF siRNA for 48 h (g). GSH level in SH-SY5Y cells transfected with MafF siRNA (10 nM) for 48 h with or without Aβ (20 μM) treatment (6 h) (h) (). The relative expressions of proteins were normalized to GAPDH. All data were presented as ; and versus the C57 group, the sham group, the control group, or the NC group; ^# versus the NC+Aβ group.

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