Research Article
Detection of BRAF V600E Mutation in Ganglioglioma and Pilocytic Astrocytoma by Immunohistochemistry and Real-Time PCR-Based Idylla Test
Table 2
BRAF V600 mutations detected or not by Idylla™ in BRAF-VE1-positive or equivocal cases.
| | Sample no. | Histopathological diagnosis | Sex | Age | Tumor location | IHC staining intensity | Category of % stained cells | IRS | BRAF V600E Idylla |
| | 1 | Ganglioglioma
(WHO grade I) | M | 23 | Hippocampus | 2+ | 4 | 8 | V600E/V600E2/V600D | | 2 | Ganglioglioma
(WHO grade I) | M | 51 | Left temporal lobe | Equivocal | V600E/V600E2/V600D | | 3 | Ganglioglioma
(WHO grade I) | M | 47 | Left frontal lobe | Equivocal | WT | | 4 | Pilocytic astrocytoma
(WHO grade I) | F | 31 | Left hemisphere | 1+ | 4 | 4 | V600E/V600E2/V600D | | 5 | Pilocytic astrocytoma
(WHO grade I) | M | 18 | Left temporal lobe | 2+ | 4 | 8 | V600E/V600E2/V600D | | 6 | Pilocytic astrocytoma
(WHO grade I) | M | 18 | Left temporal lobe | 2+ | 3 | 6 | V600E/V600E2/V600D | | 7 | Pilocytic astrocytoma
(WHO grade I) | F | 21 | Cerebellar vermis | 3+ | 3 | 9 | V600E/V600E2/V600D | | 8 | Pilocytic astrocytoma
(WHO grade I) | M | 22 | Left temporal lobe | 2+ | 4 | 8 | V600E/V600E2/V600D | | 9 | Pilocytic astrocytoma
(WHO grade I) | M | 31 | Right temporal lobe | Equivocal | WT | | 10 | Pilocytic astrocytoma
(WHO grade I) | M | 31 | Lateral ventricle | Equivocal | WT |
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