Clinical Significance of Pre-to-Postoperative Dynamics of Aspartate Transaminase/Alanine Transaminase Ratio in Predicting the Prognosis of Renal Cell Carcinoma after Surgical Treatment

Table 1

Baseline demographics of patients with renal cell carcinoma following radical nephrectomy.

Clinicopathological variables
No. of patients	670
Age at surgery
Median (yr)	55 (48–64)
<60 years	411 (61.3)
≥60 years	259 (38.7)
Sex
Male	473 (70.6)
Female	197 (29.4)
BMI (kg/m^2)
Median	24.5 (22.4–28.6)
<25	370 (55.2)
≥25	300 (44.8)
Preoperative AST/ALT ratio
Median	1.00 (0.79–1.27)
≤1.00 (lower)	317 (47.3)
>1.00 (higher)	353 (52.7)
Postoperative AST/ALT ratio
Median	1.12 (0.86–1.36)
≤1.12 (lower)	341 (50.9)
>1.12 (higher)	329 (49.1)
AST/ALT dynamics (pre-to-postoperative)
Lower → lower	228 (34.0)
Lower → higher	89 (13.3)
Higher → lower	114 (17.0)
Higher → higher	239 (35.7)
Laterality
Left	322 (48.1)
Right	348 (51.9)
Tumor size (cm)
Median	5.0 (3.9–6.5)
<7.0	546 (81.5)
≥7.0	124 (18.5)
Histology
Clear cell	573 (85.5)
Nonclear cell	93 (13.9)
Missing data	4 (0.6)
pT stage
pT1–2	520 (77.6)
pT3–4	150 (22.4)
Fuhrman grade
Low (grade 1–2)	198 (29.6)
High (grade 3–4)	461 (68.8)
Missing data	11 (1.6)
Survival outcomes
All-cause death	108 (16.1)
Cancer-specific death	78 (11.6)
Median F/U duration (mon)	59 (41–81)