How Does Endothelial Permeability Affect the Development of Juvenile Idiopathic Arthritis? Vascular Endothelial Cadherin as a Promising New Tool Helpful in the Diagnostic Process

<div>Functioning of VE-cadherin within inflamed tissues. The extracellular domain of VE-cadherin may be released after tyrosine phosphorylation at site Y685 in its cytoplasmic tail, which may be induced by triggers, e.g., TNF, histamine, and PAF. It may also be proteolyzed by enzymes from activated leukocytes, e.g., metalloproteinases, cathepsin G, and elastase. <i>β</i>-c: beta-catenin; JUP: junction plakoglobin; PAF: platelet-activating factor; TNF: tumor necrosis factor; VE-cadherin: vascular endothelial cadherin; VE-PTP: vascular endothelial protein tyrosine phosphatase.</div>

Disease Markers

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Figure 1: How Does Endothelial Permeability Affect the Development of Juvenile Idiopathic Arthritis? Vascular Endothelial Cadherin as a Promising New Tool Helpful in the Diagnostic Process 

Figure 1 | How Does Endothelial Permeability Affect the Development of Juvenile Idiopathic Arthritis? Vascular Endothelial Cadherin as a Promising New Tool Helpful in the Diagnostic Process 