Review Article
A Systematic Review and Meta-Analysis for the Association of Gene Polymorphisms in RAN with Cancer Risk
Table 3
The meta-analysis of the association between RAN SNPs and cancer risk.
| | SNP | | Heterozygote vs. wild homozygote | Variant homozygote vs. wild homozygote | Dominant model | Recessive model | Allelic model | | OR (95% CI) | (%) | | OR (95% CI) | (%) | | OR (95% CI) | (%) | | OR (95% CI) | (%) | | OR (95% CI) | (%) |
| | rs14035 C>T | 5 | 0.035 | 0.85 (0.73-0.99) | 16.6 | 0.520a | 1.22 (0.67-2.24) | 57.7 | 0.102 | 0.88 (0.76-1.03) | 43.9 | 0.338a | 1.31 (0.75-2.27) | 50.6 | 0.452a | 0.93 (0.76-1.13) | 55.9 | | Ethnicity | | Asian | 4 | 0.086 | 0.86 (0.72-1.02) | 35.3 | 0.425a | 1.39 (0.62-3.15) | 63.5 | 0.311a | 0.87 (0.66-1.14) | 55.6 | 0.293a | 1.49 (0.71-3.15) | 57.4 | 0.629a | 0.94 (0.72-1.22) | 65.1 | | Caucasian | 1 | 0.196 | 0.79 (0.56-1.13) | NA | 0.645 | 0.87 (0.47-1.61) | NA | 0.203 | 0.81 (0.58-1.12) | NA | 0.899 | 0.96 (0.53-1.75) | NA | 0.299 | 0.87 (0.67-1.13) | NA | | Source of controls | | HB | 2 | 0.011 | 0.71 (0.54-0.93) | 0.0 | 0.273 | 0.70 (0.37-1.33) | 0.0 | 0.009 | 0.71 (0.55-0.92) | 0.0 | 0.472 | 0.79 (0.42-1.50) | 0.0 | 0.014 | 0.76 (0.61-0.95) | 0.0 | | PB | 3 | 0.431 | 0.93 (0.77-1.12) | 0.0 | 0.216a | 1.72 (0.73-4.05) | 66.7 | 0.892 | 0.99 (0.82-1.19) | 18.7 | 0.153a | 1.77 (0.81-3.89) | 61.7 | 0.532 | 1.05 (0.90-1.22) | 38.9 | | rs3803012 A > G | 6 | 0.913 | 1.01 (0.89-1.14) | 0.0 | 0.022 | 2.06 (1.11-3.83) | 0.0 | 0.587 | 1.04 (0.91-1.17) | 0.0 | 0.022 | 2.06 (1.11-3.83) | 0.0 | 0.324 | 1.06 (0.94-1.20) | 0.0 | | Cancer type | | HCC | 3 | 0.676 | 0.96 (0.80-1.16) | 0.0 | 0.240 | 1.85 (0.66-5.16) | 35.6 | 0.827 | 0.98 (0.81-1.18) | 0.0 | 0.245 | 1.84 (0.66-5.12) | 37.2 | 0.999 | 1.00 (0.84-1.19) | 0.0 | | Hormone-responsive cancer | 2 | 0.940a | 1.01 (0.77-1.34) | 51.9 | 0.071 | 2.17 (0.94-5.05) | 0.0 | 0.533 | 1.06 (0.88-1.28) | 23.5 | 0.069 | 2.19 (0.94-5.08) | 0.0 | 0.312 | 1.10 (0.92-1.31) | 0.0 | | HNC | 1 | 0.474 | 1.15 (0.79-1.68) | NA | 0.400 | 2.32 (0.33-16.56) | NA | 0.400 | 1.17 (0.81-1.70) | NA | 0.409 | 2.29 (0.32-16.30) | NA | 0.341 | 1.19 (0.83-1.70) | NA | | Source of controls | | HB | 1 | 0.785 | 1.06 (0.70-1.60) | NA | 0.717 | 1.25 (0.38-4.14) | NA | 0.721 | 1.08 (0.72-1.60) | NA | 0.729 | 1.24 (0.37-4.09) | NA | 0.668 | 1.08 (0.76-1.55) | NA | | PB | 5 | 0.979 | 1.00 (0.88-1.14) | 0.0 | 0.015 | 2.47 (1.19-5.13) | 0.0 | 0.649 | 1.03 (0.90-1.18) | 0.0 | 0.015 | 2.48 (1.19-5.14) | 0.0 | 0.371 | 1.06 (0.93-1.20) | 0.0 |
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Note: a was calculated by the random model; OR, odds ratio; CI, confidence interval; NA, not available. The results are in italics if . |
