A Systematic Review and Meta-Analysis for the Association of Gene Polymorphisms in RAN with Cancer Risk
Table 5
FPRP values for the association between RAN SNPs and cancer risk.
Genotype
OR (95% CI)
Statistical powera
Prior probabilityb
0.25
0.1
0.01
0.001
0.0001
rs14035 C>T
CT vs. CC (overall)
0.85 (0.73-0.99)
0.035
0.226
0.453
0.633
0.940
0.994
0.999
CT vs. CC (HB)
0.71 (0.54-0.93)
0.011
0.227
0.205
0.350
0.830
0.980
0.998
CT+TT vs. CC (HB)
0.71 (0.55-0.92)
0.009
0.233
0.171
0.301
0.796
0.975
0.997
T vs. C (HB)
0.76 (0.61-0.95)
0.014
0.300
0.199
0.341
0.825
0.979
0.998
rs3803012 A>G
GG vs. AA (overall)
2.06 (1.11-3.83)
0.022
<0.001
0.992
0.996
1.000
1.000
1.000
GG vs. AG+AA (overall)
2.06 (1.11-3.83)
0.022
<0.001
0.992
0.996
1.000
1.000
1.000
GG vs. AA (PB)
2.47 (1.19-5.13)
0.015
<0.001
0.988
0.994
0.999
1.000
1.000
GG vs. AG+AA (PB)
2.48 (1.19-5.14)
0.015
<0.001
0.988
0.994
0.999
1.000
1.000
Note: FPRP, false-positive report probability; OR, odds ratio; CI, confidence interval. aThe statistical power is calculated using the number of observations and ORs and values. bThe results are in italics if .
