Association of TLR-2 Gene Polymorphisms with the Risk of Periodontitis: A Meta-Analysis

Table 1

Main characteristics of included studies.

References

Country

Ethnicity

Disease type

Genotype method

Polymorphism

Case/control ()

Smoke status

HWE in controls

NOS

11

12

22

Total

Fábio (2019)

Denmark

Caucasian

CP

PCR–RFLP

rs1898830 (A>G); rs5743704 (C>A); rs5743708 (G>A)

21/14; 83/69; 85/72

45/34; 3/4; 1/1

20/25; 0/0; 0/0

86/73; 86/73; 86/73

NR

0.68; 0.81; 0.95

7

Ding (2015)

China

Asian

CP

PCR–RFLP

rs1898830; rs13150331 (A>G); rs3804100 (T>C)

190/62; 177/64; 221/79

339/131; 350/129; 245/108

136/62; 141/64; 176/63

665/255; 668/257; 642/250

Mixed

0.66; 0.95; 0.036

7

Richter (2012)

Germany

Caucasian

CP/AgP

TaqMan

rs1898830; rs3804100; rs5743704; rs5743708

667/1487; 1300/1571; 1394/1662; 1343/1653

634/781; 197/213; 112/126; 101/117

177/188; 5/5; 4/5; 3/1

1478/2456; 1502/1789; 1510/1793; 1447/1771

NR

0.001; 0.43; 0.12; 0.46

7

YU (2011)

China

Asian

CP

TaqMan

rs13150331; rs1898830; rs3804100

167/36; 181/34; 157/33

328/68; 315/70; 223/56

128/36; 124/34; 203/40

623/140; 620/138; 583/129

Mixed

0.73; 0.86; 0.14

6

Takahashi (2011)

Japanese

Asian

AgP

PCR–RFLP

rs3804100

12/97

20/78

6/15

38/190

NR

0.90

7

Sahingur 2011

USA

Caucasian

CP

TaqMan

rs5743708

105/74

9/3

0/0

114/77

Mixed

0.86

7

Schulz 2010

Germany

Caucasian

AgP/CP

PCR–RFLP

rs5743708

130/79

9/2

0/0

139/81

NR

0.91

7

Holla 2010

Czech

Caucasian

CP

PCR–RFLP

rs5743708

203/244

19/15

0/0

222/259

Mixed

0.63

8

ZHU 2008

China

Asian

AgP/CP

PCR–RFLP

rs12191786 (C>T); rs5743708

0/0; 90/94

90/100; 0/6

0/0; 0/0

90/100; 90/100

NR

0.001; 0.75

7

Fukusaki 2007

Japanese

Asian

CP

PCR–RFLP

rs3804100

66/56

21/30

5/8

92/94

NR

0.18

7

Emingil (2007)

Turkey

Caucasian

AgP

PCR–RFLP

rs5743708

83/136

7/19

0/0

90/155

Mixed

0.41

8

Berdeli (2007)

Turkey

Caucasian

CP

PCR–RFLP

rs5743708

72/92

11/14

0/0

83/106

Mixed

0.47

8

Rao (2006)

China

Asian

AgP/CP

PCR–RFLP

rs12191786; rs5743708

0/0; 90/94

90/100; 0/6

0/0; 0/0

188/185; 90/100

NR

0.001; 0.76

6

Folwaczny (2004)

Germany

Caucasian

CP

PCR–RFLP

rs5743708; rs12191786

Only allele number available

NR

Unknown

5

TLR-2: toll-like receptor-2; CP: chronic periodontitis; AgP: aggressive periodontitis; 1: wild; 2: mutant; HWE: Hardy–Weinberg equilibrium; (A value less than 0.05 of HWE was considered significant); Smoke status: NR: not reported; NOS: Newcastle-Ottawa scale.