Radixin Relocalization and Nonmuscle α-Actinin Expression Are Features of Remodeling Cardiomyocytes in Adult Patients with Dilated Cardiomyopathy

Figure 5

Nonmuscle α-actinin-1 (Actn1) is reexpressed and involved in remodeling of the area of the intercalated disc in patients with dilated cardiomyopathy. (a) Nonmuscle α-actinin-1 (Actn1) is completely absent in normal cardiomyocytes of the adult heart (CON). (b) Actn1 is reexpressed in myocytes of the failing human heart (HF). Note the formation of elongations (yellow arrows) from the area of the intercalated disc and the cross-striated pattern of Actn1-positive cardiomyocytes (white arrows). (c) Actn1 is present in myocytes of the myocardium of a 2-month- (2 m-) old patient with tetralogy of Fallot but absent in older infants (3 (3 m) and 6 (6 m) months). Note the cross-striated pattern of cardiomyocytes in the magnified image (yellow rectangle, long yellow arrows). (d) Actn1 is strongly expressed in cardiomyocytes of 3-day-old rat (NEO 3d) but is absent in the adult heart (Adult). Note that vessels and interstitial cells also express Actn1.

(a)

(b)

(c)

(d)