Radixin Relocalization and Nonmuscle α-Actinin Expression Are Features of Remodeling Cardiomyocytes in Adult Patients with Dilated Cardiomyopathy

Table 1

Clinical data of the analyzed patients. Six patients (3 females and 3 males) developed the phenotype of dilated cardiomyopathy (DCM) without signs of coronary heart disease (CHD) who had undergone heart transplantation (HTX). Left ventricular ejection fraction (LVEF) was lower than 20%. Four patients have aortic stenosis (AoSt) and preserved ejection fraction ( 2 males and 2 females). Three pediatric patients with tetralogy of Fallot (ToF) served for comparison. NYHA: New York Heart Association; PCI: percutaneous coronary intervention; CABG: coronary artery bypass grafting; AK-OP: aortic valve surgery; MK-OP: mitral valve surgery; bivICD: biventricular implantable cardioverter-defibrillator; ACE: angiotensin-converting enzyme; AT1: angiotensin II receptor; ASS: acetylsalicylic acid; CRP: C-reactive protein; LDH: lactate dehydrogenase; SGOT: serum oxaloacetic transaminase; SGPT: serum glutamic pyruvic transaminase; CK: creatine kinase; NT-pro-BNP: N-terminal probrain natriuretic peptide; PTT: activated and partial thromboplastin time; INR: international normalized ratio; HIV: human immunodeficiency virus; LVESD: left ventricular end-systolic diameter; LVEDD: left ventricular end-diastolic diameter; PVR: pulmonary vascular resistance; PCWP: pulmonary capillary wedge pressure.

Demographic and risk factors	DCM ()	AoSt ()	ToF ()
Number of patients	6	4	3
DCM	6	0	0
CHD	0	0	0
Etiology of DCM	3xi.p., 2xfam, 1xpp	0	0
Age	years	years	2, 3, and 6 months
Gender	3 females, 3 males	2 females, 2 males	1 females, 2 males
NYHA class		3	0
Body height (cm)
Weight (kg)
Prior myocardial infarction	0	0	0
Prior PCI or CABG	0	0	0
Prior smoking	2	1	0
Prior hypertension	1	3	0
Prior COPD	1	0	0
Prior diabetes mellitus	0	1	0
Thrombocytopenia	0	0	0
Prior hypercholesterolemia	1	1	0
Pre-CABG	0	0	0
Pre-HTXLVAD	0	0	0
Pre-HTXAK-OP	1	0	0
Pre-HTXMK-OP	1	0	0
Pre-HTXbivICD	5	0	0
Cardiac arrhythmia	3	1	0
Comedication
Beta blocker (%)	6	4	3
ACE inhibitor and/or AT1 antagonist (%)	4	4	0
Diuretic (%)	6	2	0
Digitalis (%)	0	1	0
Aldosterone antagonist (%)	4	1	0
Sildenafil 20 mg (%)	2	0	0
ASS (%)	0	2	0
Amiodarone (%)	2	0	0
L-Thyroxin (%)	1	1	0
Statins (%)	1	0	0
Laboratory parameters
Sodium (mmol/l)
Potassium (mmol/l)
Creatinine (mg/dl)			0.2
Hemoglobin (g/dl)
Hematocrit (%)			0.37
CRP (mg/l)			<0.5
Leukocytes (Ts/μl)
Total cholesterol (mg/dl)			n.d.
LDHU (l)
SGOT (IU/l)
SGPT (IU/l)
CKU (l)
NT-pro-BNP (pg/ml)
Quick (thromboplastin time) (%)
PTT (s)
INR		1.3 ± 0.2	1 ± 0.1
Hepatitis B & C, HIV	0	0	0
Echo characteristics
LVEF (%)			n.d.
LVESD (mm)			n.d.
LVEDD (mm)			n.d.
Hemodynamic parameters
Cardiac index (l/minm)	()	n.d.	n.d.
PVR (dyness/cm^5)		n.d.	n.d.
PCWP (mmHg)		n.d.	n.d.
O2 saturation (%)		n.d.	n.d.