Nine Genes Mediate the Therapeutic Effects of Iodine-131 Radiotherapy in Thyroid Carcinoma Patients

Table 1

The results of enrichment analysis for the 428 genes in the green module (top 10 listed).

Category	Description	Count	adjust	value
Biological process	GO:0003013~circulatory system process	49
	GO:0008015~blood circulation	48
	GO:0043062~extracellular structure organization	39
	GO:1901342~regulation of vasculature development	37
	GO:0030198~extracellular matrix organization	33
	GO:0032835~glomerulus development	15
	GO:0045765~regulation of angiogenesis	34
	GO:0002040~sprouting angiogenesis	23
	GO:0001570~vasculogenesis	15
	GO:0001667~ameboidal-type cell migration	34
Cell component	GO:0031012~extracellular matrix	34
	GO:0062023~collagen-containing extracellular matrix	25
	GO:0043235~receptor complex	27
	GO:0043292~contractile fiber	18
	GO:0044449~contractile fiber part	17
	GO:0005604~basement membrane	11
	GO:0045177~apical part of cell	23
	GO:1902495~transmembrane transporter complex	21
	GO:0098857~membrane microdomain	20
	GO:1990351~transporter complex	21
Molecular function	GO:0015267~channel activity	29
	GO:0022803~passive transmembrane transporter activity	29
	GO:0022838~substrate-specific channel activity	27
	GO:0005216~ion channel activity	26
	GO:0008528~G protein-coupled peptide receptor activity	14
	GO:0001653~peptide receptor activity	14
	GO:0005201~extracellular matrix structural constituent	14
	GO:0019838~growth factor binding	13
	GO:0004115~3,5-cyclic-AMP phosphodiesterase activity	5
	GO:0071813~lipoprotein particle binding	6
Pathway	hsa04510~focal adhesion	20
	hsa04022~cGMP-PKG signaling pathway	18
	hsa04015~Rap1 signaling pathway	19
	hsa04512~ECM-receptor interaction	12
	hsa04151~PI3K-Akt signaling pathway	25
	hsa05032~morphine addiction	12
	hsa04270~vascular smooth muscle contraction	14
	hsa04020~calcium signaling pathway	16
	hsa04611~platelet activation	12
	hsa05165~human papillomavirus infection	21

GO: Gene Ontology.