Nine Genes Mediate the Therapeutic Effects of Iodine-131 Radiotherapy in Thyroid Carcinoma Patients

Table 2

The Gene Ontology (GO) functional terms and pathways enriched for the 53 hub genes.

Category	Description	Count	adjust
Biological process	GO:0003158~endothelium development	7
	GO:0001570~vasculogenesis	6
	GO:0048010~vascular endothelial growth factor receptor signaling pathway	6
	GO:0030947~regulation of vascular endothelial growth factor receptor signaling pathway	4
	GO:0045602~negative regulation of endothelial cell differentiation	3
	GO:0045601~regulation of endothelial cell differentiation	4
	GO:0045446~endothelial cell differentiation	5
	GO:0061298~retina vasculature development in camera-type eye	3
	GO:0045765~regulation of angiogenesis	7
	GO:0090287~regulation of cellular response to growth factor stimulus	6
	GO:1901342~regulation of vasculature development	7
	GO:0001935~endothelial cell proliferation	5
	GO:0045766~positive regulation of angiogenesis	5
	GO:0031589~cell-substrate adhesion	6
	GO:0038084~vascular endothelial growth factor signaling pathway	3
Cell component	GO:0043235~receptor complex	8
	GO:0005911~cell-cell junction	7
Molecular function	GO:0019199~transmembrane receptor protein kinase activity	5
	GO:0004714~transmembrane receptor protein tyrosine kinase activity	4
	GO:0019838~growth factor binding	5
	GO:0070888~E-box binding	3
Pathway	hsa04510~focal adhesion	4
	hsa04015~Rap1 signaling pathway	4
	hsa04670~leukocyte transendothelial migration	3