Selected Metal Matrix Metalloproteinases and Tissue Inhibitors of Metalloproteinases as Potential Biomarkers for Tubulointerstitial Fibrosis in Children with Unilateral Hydronephrosis

Table 2

The results of serum concentrations of MMPs and TIMPs in study A, B, and C and control groups.

Variable	Group		Median	Range	Statistical analysis
MMP-1 (pg/ml)	A	25	297.5	410.0-1116.0	A vs. controls
	B	11	365.3	800.0-604.5	B vs. controls
	C	9	440.1	150.0-930.0	C vs. controls
	Controls	21	326.1	209.1-607.1
MMP-2 (pg/ml)	A	25			A vs. controls
	B	11			B vs. controls
	C	9			C vs. controls
	Controls	21
MMP-9 (pg/ml)	A	25			A vs. controls
	B	11			B vs. controls
	C	9			C vs. controls
	Controls	21
TIMP-1 (pg/ml)	A	25			A vs. controls
	B	11			B vs. controls
	C	9			C vs. controls
	Controls	21
TIMP-2 (pg/ml)	A	25			A vs. controls
	B	11			B vs. controls
	C	9			C vs. controls
	Controls	21
MMP-1/TIMP-1	A	25	0.13	0.02-0.2	A vs. controls
	B	11	0.14	0.02-0.26	B vs. controls
	C	9	0.13	0.04-0.29	C vs. controls
	Controls	21	0.1	0.03-0.35
MMP-2/TIMP-1	A	25	1.6	0.6-2.9	A vs. controls
	B	11	1.7	1.1-3.1	B vs. controls
	C	9	1.6	1.2-2.0	C vs. controls
	Controls	21	2.9	2.4-3.4
MMP-9/TIMP-1	A	25	0.03	0.01-0.1	A vs. controls
	B	11	0.04	0.01-0.1	B vs. controls
	C	9	0.15	0.1-2.1	C vs. controls
	Controls	21	0.1	0.1-0.2
MMP-1/TIMP-2	A	25	0.09	0.04-0.2	A vs. controls
	B	11	0.05	0.01-0.2	B vs. controls
	C	9	0.07	0.03-0.14	C vs. controls
	Controls	21	0.06	0.02-0.1
MMP-2/TIMP-2	A	25	3.2	0.6-5.0	A vs. controls
	B	11	3.4	2.8-5.3	B vs. controls
	C	9	3.0	1.9-4.8	C vs. controls
	Controls	21	3.3	2.0-5.0
MMP-9/TIMP-2	A	25	0.02	0.01-0.3	A vs. controls
	B	11	0.03	0.01-0.3	B vs. controls
	C	9	0.1	0.07-0.3	C vs. controls
	Controls	21	0.09	0.03-0.28