Genetic Polymorphisms of MMP1, MMP9, COL1A1, and COL1A2 in Polish Patients with Thoracic Aortopathy

Table 1

Clinical characteristics of the studied patients.

Variable	Control group ()	AsAA ()	TAD ()
Age (years)	60 (36-78)	60 (28-79)	57 (31-81)
BMI (kg/m^2)	27.3 (19.0-40.0)	28.3 (20.0-38.1)	26.1 (16.1-39.9)^a
Males	26 (43%)	34 (72%)^c	30 (61%)
Smoking	10 (16%)	17 (36%)^d	15 (31%)
Diabetes mellitus	12 (20%)	7 (15%)	0 (0%)^a,c
Hypertension	33 (54%)	34 (72%)	27 (55%)
BAV	-	24 (51%)	6 (12%)^a
^#	-	35 (74%)	32 (65%)

AsAA: ascending aortic aneurysm; TAD: thoracic aortic dissection; BMI: body mass index; BAV: bicuspid aortic valve; AVR: aortic valve regurgitation. ^∗Chi2 test for qualitative variables and Mann-Whitney test for quantitative variables. ^#Aortic valve regurgitation (AVR) was measured using rank scale (“-” = 0, “+” = 1, “++” = 2, “+++” = 3, “++++” = 4), and the study group was divided, depending on the degree of regurgitation, into two subgroups: low regurgitation () and large () regurgitation. ^a as compared to the AsAA group; ^c and ^d as compared to the control group.