[Retracted] Relationship between Long Noncoding RNA H19 Polymorphisms and Risk of Coronary Artery Disease in a Chinese Population: A Case-Control Study
Table 2
Associations between lncRNA H19 polymorphisms and risk of acute coronary syndrome stratified by host characteristics.
Variables
Genotype
ACS vs. CON
a
OR (95% CI)
H19 rs2735971
Gender
Male
GG
176/162
1 (Ref.)
GA
65/93
0.024
0.64 (0.44-0.94)
AA
7/4
0.452
1.61 (0.46-5.62)
GA+AA vs. GG
0.045
0.68 (0.47-0.99)
AA vs. GA+GG
0.330
1.85 (0.54-6.41)
A vs. G
0.137
0.78 (0.66-1.08)
Female
GG
63/49
1 (Ref.)
GA
14/25
0.028
0.43 (0.20-0.91)
AA
2/6
0.101
0.25 (0.05-1.31)
GA+AA vs. GG
0.012
0.40 (0.19-0.82)
AA vs. GA+GG
0.174
0.32 (0.06-1.65)
A vs. G
0.007
0.43 (0.23-0.79)
Age
≦60
GG
143/121
1 (Ref.)
GA
51/76
0.010
0.57 (0.37-0.88)
AA
5/3
0.783
1.23 (0.28-5.34)
GA+AA vs. GG
0.017
0.60 (0.39-0.91)
AA vs. GA+GG
0.529
1.59 (0.37-6.80)
A vs. G
0.064
0.65 (0.41-1.03)
>60
GG
96/90
1 (Ref.)
GA
28/42
0.134
0.65 (0.37-1.14)
AA
4/7
0.444
0.60 (0.17-2.20)
GA+AA vs. GG
0.102
0.64 (0.37-1.09)
AA vs. GA+GG
0.525
0.66 (0.19-2.37)
A vs. G
0.056
0.70 (0.49-1.01)
Smoking
Ever smoker
GG
161/112
1 (Ref.)
GA
58/63
0.041
0.63 (0.41-0.98)
AA
5/4
0.903
0.92 (0.24-3.52)
GA+AA vs. GG
0.047
0.65 (0.43-0.99)
AA vs. GA+GG
0.926
1.07 (0.28-4.03)
A vs. G
0.087
0.72 (0.50-1.05)
Never smoker
GG
78/99
1 (Ref.)
GA
21/55
0.026
0.51 (0.28-0.92)
AA
4/6
0.675
0.76 (0.20-2.81)
GA+AA vs. GG
0.028
0.54 (0.31-0.94)
AA vs. GA+GG
0.901
0.92 (0.25-3.39)
A vs. G
0.055
0.63 (0.39-1.01)
Alcohol drinking
Drinker
GG
56/119
1 (Ref.)
GA
27/76
0.345
0.77 (0.45-1.33)
AA
4/4
0.314
2.08 (0.50-8.63)
GA+AA vs. GG
0.491
0.83 (0.49-1.41)
AA vs. GA+GG
0.256
2.27 (0.55-9.28)
A vs. G
0.806
0.95 (0.62-1.48)
Nondrinker
GG
183/92
1 (Ref.)
GA
52/42
0.041
0.60 (0.37-0.98)
AA
5/6
0.298
0.52 (0.15-1.79)
GA+AA vs. GG
0.028
0.59 (0.37-0.94)
AA vs. GA+GG
0.417
0.60 (0.18-2.05)
A vs. G
0.027
0.63 (0.42-0.95)
H19 rs2839698
Gender
Male
CC
140/139
1 (Ref.)
CT
111/109
0.934
1.02 (0.71-1.45)
TT
17/28
0.109
0.59 (0.31-1.13)
CT+TT vs. CC
0.669
0.93 (0.66-1.30)
TT vs. CT+CC
0.112
0.60 (0.32-1.13)
T vs. C
0.305
0.87 (0.67-1.13)
Female
CC
41/61
1 (Ref.)
CT
37/21
0.005
2.61 (1.34-5.09)
TT
9/5
0.097
2.68 (0.84-8.58)
CT+TT vs. CC
0.002
2.62 (1.40-4.88)
TT vs. CT+CC
0.284
1.86 (0.60-5.81)
T vs. C
0.004
2.12 (1.28-3.50)
Age
≦60
CC
113/111
1 (Ref.)
CT
80/84
0.710
0.93 (0.62-1.39)
TT
17/20
0.589
0.82 (0.41-1.66)
CT+TT vs. CC
0.640
0.91 (0.62-1.34)
TT vs. CT+CC
0.671
0.86 (0.44-1.70)
T vs. C
0.147
1.31 (0.91-1.89)
>60
CC
68/89
1 (Ref.)
CT
68/46
0.006
2.02 (1.22-3.34)
TT
9/13
0.997
1.00 (0.40-2.51)
CT+TT vs. CC
0.015
1.80 (1.12-2.89)
TT vs. CT+CC
0.511
0.74 (0.30-1.81)
T vs. C
0.603
0.92 (0.68-1.25)
Smoking
Ever smoker
CC
126/93
1 (Ref.)
CT
103/79
0.968
0.99 (0.66-1.48)
TT
14/20
0.062
0.49 (0.23-1.04)
CT+TT vs. CC
0.552
0.89 (0.61-1.31)
TT vs. CT+CC
0.073
0.52 (0.25-1.06)
T vs. C
0.221
0.83 (0.62-1.12)
Never smoker
CC
55/107
1 (Ref.)
CT
45/51
0.041
1.72 (1.02-2.90)
TT
12/13
0.172
1.81 (0.77-4.24)
CT+TT vs. CC
0.023
1.76 (1.08-2.87)
TT vs. CT+CC
0.332
1.51 (0.66-3.47)
T vs. C
0.024
1.56 (1.06-2.29)
Alcohol drinking
Drinker
CC
51/111
1 (Ref.)
CT
35/80
0.794
0.93 (0.55-1.57)
TT
6/21
0.262
0.58 (0.22-1.51)
CT+TT vs. CC
0.557
0.86 (0.53-1.41)
TT vs. CT+CC
0.302
0.61 (0.24-1.56)
T vs. C
0.352
0.83 (0.56-1.23)
Nondrinker
CC
130/50
1 (Ref.)
CT
113/50
0.094
1.45 (0.94-2.25)
TT
20/12
0.736
1.15 (0.52-2.53)
CT+TT vs. CC
0.106
1.40 (0.93-2.12)
TT vs. CT+CC
0.985
0.99 (0.47-2.12)
T vs. C
0.205
1.24 (0.89-1.72)
H19 rs3024270
Gender
Male
GG
91/83
1 (Ref.)
GC
139/125
0.943
1.01 (0.69-1.49)
CC
37/63
0.018
0.54 (0.33-0.90)
CC+GC vs. GG
0.394
0.85 (0.60-1.23)
CC vs. GC+GG
0.006
0.53 (0.34-0.83)
C vs. G
0.035
0.77 (0.61-0.98)
Female
GG
29/37
1 (Ref.)
GC
40/37
0.311
1.41 (0.73-2.74)
CC
16/14
0.385
1.47 (0.62-3.50)
CC+GC vs. GG
0.266
1.42 (0.77-2.64)
CC vs. GC+GG
0.610
1.23 (0.56-2.70)
C vs. G
0.289
1.26 (0.82-1.95)
Age
≦60
GG
74/69
1 (Ref.)
GC
102/91
0.914
1.02 (0.66-1.58)
CC
33/51
0.081
0.61 (0.35-1.06)
CC+GC vs. GG
0.526
0.88 (0.59-1.32)
CC vs. GC+GG
0.033
0.59 (0.36-0.96)
C vs. G
0.868
0.97 (0.70-1.35)
>60
GG
46/51
1 (Ref.)
GC
77/71
0.424
1.24 (0.73-2.11)
CC
20/26
0.883
0.95 (0.46-1.95)
CC+GC vs. GG
0.556
1.16 (0.71-1.92)
CC vs. GC+GG
0.621
0.85 (0.46-1.62)
C vs. G
0.106
0.79 (0.61-1.05)
Smoking
Ever smoker
GG
81/56
1 (Ref.)
GC
126/86
0.935
1.02 (0.65-1.59)
CC
34/45
0.029
0.53 (0.30-0.94)
CC+GC vs. GG
0.445
0.85 (0.56-1.29)
CC vs. GC+GG
0.009
0.51 (0.31-0.85)
C vs. G
0.050
0.76 (0.58-1.00)
Never smoker
GG
39/64
1 (Ref.)
GC
53/76
0.715
1.11 (0.65-1.89)
CC
19/32
0.992
1.00 (0.50-2.01)
CC+GC vs. GG
0.731
1.09 (0.66-1.81)
CC vs. GC+GG
0.805
0.92 (0.49-1.74)
C vs. G
0.920
1.02 (0.72-1.44)
Alcohol drinking
Drinker
GG
31/62
1 (Ref.)
GC
48/99
0.960
0.99 (0.57-1.72)
CC
13/46
0.135
0.56 (0.26-1.20)
CC+GC vs. GG
0.537
0.85 (0.50-1.44)
CC vs. GC+GG
0.092
0.56 (0.29-1.10)
C vs. G
0.171
0.78 (0.55-1.11)
Nondrinker
GG
89/58
1 (Ref.)
GC
131/63
0.281
1.29 (0.81-2.04)
CC
40/31
0.541
0.83 (0.46-1.50)
CC+GC vs. GG
0.539
1.14 (0.75-1.75)
CC vs. GC+GG
0.214
0.72 (0.42-1.21)
C vs. G
0.800
0.96 (0.72-1.29)
aLogistic regression adjusted by sex and age. ACS: acute coronary syndrome; CI: confidence interval; CON: control; OR: odds ratio.
