Development of a Ferroptosis-Related lncRNA Signature to Predict the Prognosis and Immune Landscape of Bladder Cancer

Figure 1

Association between ferroptosis and immune infiltration. (a) Among 121 ferroptosis regulators, 14 were upregulated and 6 were downregulated in BCa samples. (b) Consensus CDF values changed from to . (c) Relative changes in area under CDF curve with different values. (d) Consensus clustering heat map of 408 BCa cases when . (e) Scatter diagram displaying the PCA results of the expression of all genes when . (f) Kaplan–Meier survival analysis with log-rank test of BCa cases in different clusters (). (g) Box plot indicating the difference in infiltration proportion of 22 different immune cells between the two clusters. (h) Heat map of different immune-related pathways and functions. (i) GSEA for patients in cluster 1. (j) GSEA for patients in cluster 2. (k) Expression profiles of common immune checkpoints between different clusters. (l) Difference in immunotherapy response between the two clusters. (m) Patients in different clusters showed different chemotherapeutic sensitivity. BCa: bladder cancer; CDF: cumulative distribution function; PCA: principal component analysis; GSEA: gene set enrichment analysis; .

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