Disease Markers / 2021 / Article / Tab 1 / Research Article
Value of the Neutrophil-Lymphocyte Ratio in Predicting COVID-19 Severity: A Meta-analysis Table 1 Characteristics of the studies included in the meta-analysis. Note: true positive (TP), true negative (TN), false positive (FP), and false negative (FN).
First author Year Country Severe Nonsevere Sensitivity Specificity TP FP FN TN Median age (severe/nonsevere) Centers Optimal cut-off Study type Xia X [8 ] 2020 China 31 32 0.84 0.75 26 8 5 24 64.55/62.25 Single 4.795 Retrospective Yang AP [9 ] 2020 China 24 69 0.88 0.63 21 25 3 44 57.9/42.1 Single 3.3 Retrospective Shang W [10 ] 2020 China 139 304 0.56 0.84 78 50 61 254 64/58 Single 4.283 Retrospective Liu J [11 ] 2020 China 37 78 0.87 0.72 32 22 5 56 NA Single 3.13 Prospective Wang W [12 ] 2020 China 50 73 0.84 0.97 42 2 8 71 79.5/61.0 Multicenter 4.16 Retrospective Wang C [13 ] 2020 China 10 35 0.83 0.82 8 6 2 29 43/38 Multicenter 13.39 Retrospective Bastug A [14 ] 2020 Turkey 46 145 0.84 0.62 39 54 7 91 71/43 Single 3.21 Retrospective Fu J [15 ] 2020 China 16 59 0.75 0.86 12 8 4 51 51.8/45.1 Single — Retrospective Liu F [16 ] 2020 China 19 115 0.94 0.50 18 57 1 58 63/50 Single — Retrospective Ok F [17 ] 2020 Turkey 54 85 0.57 0.98 31 1 23 84 68.3/47.2 Single 5.72 Retrospective Wang X [18 ] 2020 China 20 111 1 0.56 20 48 0 63 NA Single 2.306 Retrospective Fei MM [19 ] 2020 China 52 20 1 0.73 52 5 0 15 64/55.7 Single 3 Retrospective Basbus L [20 ] 2020 Argentina 21 110 0.81 0.67 17 36 4 74 77/47 Single 3 Retrospective Sun S [21 ] 2020 China 27 89 0.74 0.89 20 9 7 80 62/47 Single 4.5 Retrospective Song CY [22 ] 2020 China 42 31 0.64 0.81 27 6 15 25 55.5/34 Single 5.87 Retrospective Qin Z [23 ] 2020 China 31 17 0.81 0.88 25 2 6 15 61/45 Single 3.55 Retrospective Sayed AA [24 ] 2021 Saudi Arabia 41 660 0.86 0.79 35 139 6 521 45/35 Multicenter 5.5 Retrospective Wang K [25 ] 2021 China 5 33 0.85 0.98 4 1 1 32 60/45 Single 4.425 Retrospective Sayah W [26 ] 2021 Algeria 80 73 0.72 0.8 57 14 23 59 65/57 Single 5.9 Prospective Ghazanfari T [27 ] 2021 Iran 33 40 0.9 0.47 30 21 3 19 59.14/52.78 Single 3.53 Retrospective Noor A [28 ] 2020 Pakistan 370 365 0.94 0.57 347 157 23 208 48.11/44.47 Single — Cross-sectional Hammad R [29 ] 2021 Egypt 34 30 0.91 0.93 31 2 3 28 60/27 Single 3.1 Cross-sectional Fouad SH [30 ] 2021 Egypt 40 298 0.34 0.87 14 38 26 260 46.8 Single 7.53 Retrospective Liu L [31 ] 2020 China 92 202 0.8 0.19 74 164 18 38 62/50.1 Single 5 Retrospective Lin S [32 ] 2021 China 46 22 0.93 0.73 43 6 3 16 56.4/44 Single 3.63 Retrospective Tahtasakal CA [33 ] 2021 Turkey 136 398 0.79 0.66 107 135 29 263 66/59 Single 3.69 Retrospective Hu H [34 ] 2020 China 21 19 0.81 0.74 17 5 4 14 63/43 Single 3.84 Retrospective Qi Y [35 ] 2021 China 28 54 0.86 0.79 24 11 4 43 55.5/40 Multicenter 3.531 Retrospective Şan İ [36 ] 2021 Turkey 44 344 0.71 0.71 31 98 13 246 67.5/42 Single 3.59 Retrospective Mousavi-Nasab SD [37 ] 2020 Iran 14 56 0.71 0.64 10 20 4 36 41.3/43 Single 1 Retrospective
