The Roles of Liver Inflammation and the Insulin Signaling Pathway in PM2.5 Instillation-Induced Insulin Resistance in Wistar Rats

Table 4

Changes in liver expression of INSR, IRS-1, PI3K, AKT, and GLUT2 in rats ().

	INSR	IRS-1	PI3K	AKT	GLUT2
Control group
0.75 mg/kg PM2.5 group
2.5 mg/kg PM2.5 group					^a
5 mg/kg PM2.5 group	^abc	^abc	^a	^abc	^ab
10 mg/kg PM2.5 group	^abc	^abc	^ab	^abc	^abc
	8.210	8.434	4.753	7.026	7.571
	<0.001	<0.001	<0.001	<0.001	<0.001

Note: compared to the control group, ^a; compared to the 0.75 mg/kg PM2.5 group, ^b; compared to the 2.5 mg/kg PM2.5 group, ^c; compared to the 5 mg/kg PM2.5 group, ^d.