Genetic Polymorphisms of IFNG, IFNGR1, and Androgen Receptor and Chronic Prostatitis/Chronic Pelvic Pain Syndrome in a Chinese Han Population

Table 2

The association of allele and genotype frequencies and CP/CPPS.

Gene	SNP	Allele/genotype	Cases	Control	OR (95% CI)
			(%)	(%)
IFNG	rs2069718	A	204 (86.44)	224 (89.60)	0.74 (0.43, 1.28)	1.153	0.283
		G	32 (13.56)	26 (10.40)
		AA	89 (75.42)	100 (80.00)		1.520	0.468
		GA	26 (22.03)	24 (19.20)
		GG	3 (2.55)	1 (0.80)
	rs1861493	A	146 (61.86)	154 (61.60)	1.01 (0.70, 1.46)	0.004	0.952
		G	90 (38.14)	96 (38.40)
		AA	46 (38.98)	49 (39.20)		0.035	0.983
		GA	54 (45.76)	56 (44.80)
		GG	18 (15.26)	20 (16.00)
IFNGR1	rs10457655	G	207 (87.71)	224 (89.60)	0.83 (0.47, 1.45)	0.431	0.511
		A	29 (12.29)	26 (10.40)
		GG	91 (77.12)	99 (79.20)		2.16	0.340
		GA	25 (21.19)	26 (20.80)
		AA	2 (1.69)	0 (0.00)
	rs35860242	C	216 (91.53)	237 (94.80)	0.59 (0.29, 1.22)	2.057	0.152
		T	20 (8.47)	13 (5.20)
		CC	101 (85.59)	112 (89.60)		3.41	0.182
		CT	14 (11.87)	13 (10.40)
		TT	3 (2.54)	0 (0.00)
	rs3799488	T	178 (75.42)	185 (74.00)	1.08 (0.72, 1.62)	0.130	0.718
		C	58 (24.58)	65 (26.00)
		TT	67 (56.78)	72 (57.60)		1.40	0.496
		CT	44 (37.29)	41 (32.80)
		CC	7 (5.93)	12 (9.60)
	rs7749390	G	135 (57.20)	141 (56.40)	1.03 (0.72, 1.48)	0.032	0.858
		A	101 (42.80)	109 (43.60)
		GG	39 (33.05)	38 (30.40)		0.336	0.845
		GA	57 (48.31)	65 (52.00)
		AA	22 (18.64)	22 (17.60)
	rs9376267	C	133 (56.84)	138 (55.20)	1.07 (0.75, 1.53)	0.132	0.717
		T	101 (43.16)	112 (44.80)
		CC	35 (29.91)	38 (30.40)		0.686	0.710
		CT	63 (53.85)	62 (49.60)
		TT	19 (16.24)	25 (20.00)
	rs9376268	G	139 (59.40)	148 (58.73)	1.01 (0.70, 1.45)	0.002	0.964
		A	95 (40.60)	102 (40.80)
		GG	39 (33.33)	43 (34.12)		0.182	0.913
		GA	61 (52.14)	62 (49.21)
		AA	17 (14.53)	20 (16.00)
AR	rs138464995	C	204 (94)	238 (95)	0.86 (0.38, 1.95)	0.135	0.713
		T	12 (6)	12 (5)
		CC	102 (94)	119 (95)	0.86 (0.27, 2.74)	0.068	0.795
		TT	6 (6)	6 (5)
	rs142203174	A	212 (90)	230 (92)	0.77 (0.41, 1.43)	0.694	0.405
		C	24 (10)	20 (8)
		AA	106 (90)	115 (92)	0.77 (0.32,1.85)	0.347	0.556
		CC	12 (10)	10 (8)
	rs192195540	G	190 (81)	192 (77)	1.30 (0.84, 2.03)	1.41	0.236
		C	44 (19)	58 (23)
		GG	95 (81)	96 (77)	1.30 (0.70, 2.43)	0.702	0.402
		CC	22 (19)	29 (23)
	rs139374285	C	226 (96)	238 (95)	1.14 (0.48, 2.69)	0.089	0.766
		T	10 (4)	12 (5)
		CC	113 (96)	119 (95)	1.14 (0.34, 3.84)	0.044	0.833
		TT	5 (4)	6 (5)
	rs72627670	C	202 (86)	202 (81)	1.50 (0.92, 2.44)	2.67	0.102
		T	32 (14)	48 (19)
		CC	101 (86)	101 (81)	1.50 (0.75, 2.99)	1.34	0.248
		TT	16 (14)	24 (19)
	rs144488434	C	226 (96)	226 (90)	2.40 (1.12, 5.13)	5.37	0.021
		T	10 (4)	24 (10)
		CC	113 (96)	113 (90)	2.40 (0.82, 7.04)	2.68	0.101
		TT	5 (4)	12 (10)
	rs143099096	C	228 (97)	240 (96)	1.19 (0.46, 3.06)	0.127	0.722
		A	8 (3)	10 (4)
		CC	114 (97)	120 (96)	1.19 (0.31, 4.53)	0.000	1.000
		AA	4 (3)	5 (4)
	rs78445514	T	198 (84)	222 (89)	0.66 (0.39, 1.11)	2.49	0.115
		C	38 (16)	28 (11)
		TT	99 (84)	111 (89)	0.66 (0.31, 1.38)	1.24	0.265
		CC	19 (16)	14 (11)
	rs141340859	T	216 (92)	238 (95)	0.61 (0.29, 1.29)	1.74	0.187
		C	18 (8)	12 (5)
		TT	108 (92)	119 (95)	0.61 (0.21, 1.76)	0.870	0.351
		CC	9 (8)	6 (5)
	rs5965429	A	168 (73)	166 (67)	1.34 (0.90, 1.98)	2.12	0.146
		G	62 (27)	82 (33)
		AA	84 (73)	83 (67)	1.34 (0.77, 2.34)	1.06	0.304
		GG	31 (27)	41 (33)

CP/CPPS: chronic prostatitis/chronic pelvic pain syndrome; OR: odds ratio; SNPs: single nucleotide polymorphisms.