Identification and Validation of a Proliferation-Associated Score Model Predicting Survival in Lung Adenocarcinomas

Figure 5

TME characteristics of the two groups. (a) Infiltration patterns of immune cells for 497 LUAD patients from TCGA. Clinical and pathological features contain age, gender, stage, smoking status, and score groups. (b) The proportion of immune cells in the two groups. The scattered dots show the immune cells’ score. The median, third, and first quartile values are shown in the boxplots. ; ; ; . (c) Relationships between the 24 immune cells in LUAD patients from TCGA. (d) Violin plots show the expression profiling of the f7 immune-related genes in the POPLAR study and cytolytic activity (CYT) score. (e) Relative expression level of molecules associated with the innate immune activity (shown at left) and MHC-I/II antigen-presenting process (shown at right). (f) Violin plots displaying the CD8+ T cells/Treg ratio of the infiltration groups. (g) Relative expression level of immune coinhibitors (shown at left) and costimulators (shown at right).

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