Cysteine-Rich Intestinal Protein 1 Served as an Epithelial Ovarian Cancer Marker via Promoting Wnt/β-Catenin-Mediated EMT and Tumour Metastasis

Figure 5

The relationship between CRIP1 and EMT indicates that CRIP1 may function in ovarian cancer development via the Wnt/β-catenin pathway. (a) KEGG pathway enrichment analysis was performed to identify which pathway was significantly enriched in CRIP1-related ovarian cancer progression. (b) The effect of CRIP1 silencing on EMT-related signaling pathways. EMT markers, such as E-cadherin, N-cadherin, and vimentin proteins, were detected by western blot. (c) The effect of CRIP1 silencing on Wnt/β-catenin signaling pathway. The important molecules of this pathway, including β-catenin, GSK-3β, p-GSK-3β, MMP2, and MMP9, were assessed by western blot.

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