Cyclophosphamide Attenuates Fibrosis in Lupus Nephritis by Regulating Mesangial Cell Cycle Progression

Figure 1

(a) Renal function in lupus nephritis after CTX treatment. CTX reduced the levels of blood urea nitrogen (BUN) and serum creatinine (SCR) of lupus nephritis (LN) mice. Data are presented as the (). , , and , lupus nephritis vs. control. (b) CTX 40 mg/l inhibits cell proliferation in glomeruli and necrosis of capillary loops. Glomerular pathology was detected by HE staining and PAS staining at week 17 (, 400x original magnification).

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