Cyclophosphamide Attenuates Fibrosis in Lupus Nephritis by Regulating Mesangial Cell Cycle Progression

Figure 3

CTX reduces HMC proliferation by arresting the cell cycle in G1 phase. (a) CTX inhibited cell proliferation induced by PDGF-B at 48 h but not 24 h (). (b) Flow cytometry analysis showing cells in different phases of cell cycle. CTX arrested cells in G1 phase in a concentration-dependent manner; therefore, the percentage of cells in S phase was significantly lower (). Data are presented as the , , , and .

(a)

(b)