Research Article
CircLDLR Promotes Papillary Thyroid Carcinoma Tumorigenicity by Regulating miR-637/LMO4 Axis
Figure 2
CircLDLR knockdown suppresses cell malignant phenotypes in PTC. TPC-1 and IHH-4 cells were transfected with si-circLDLR or si-NC. (a) qRT-PCR analysis of circLDLR expression in TPC-1 and IHH-4 cells after transfection. (b, c) The proliferation analysis of TPC-1 and IHH-4 cells using CCK-8 assay and colony formation assay. (d) Flow cytometry analysis of apoptosis of TPC-1 and IHH-4 cells. (e–g) The analysis of invasion and migration abilities of TPC-1 and IHH-4 cells using transwell assay and wound healing assay. (h, i) Western blot analysis of C-caspase3, MMP2, and MMP9 protein levels. , .
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