The Key Genes Underlying Pathophysiology Association between Plaque Instability and Progression of Myocardial Infarction

Figure 2

HFD shows less effect on aging with MI. (a) Venn diagram showed DEGs of plaque samples among aged mice or young mice fed with HFD or chow, and 132 DEGs and 221 DEGs were obtained named DEG1 and DEG2. (b) Venn diagram of DEG1 and DEGs at 1 d, 1 w, and 8 w in GSE114695. (c) Venn diagram of DEG2 and DEGs at 1 d, 1 w, and 8 w in GSE114695. (d) 16 DEGs were screened out between DEG1 and DEGs at 1 d, which were enriched in lipid transport and lipid biosynthetic process. (e) 19 DEGs were screened out between DEG1 and DEGs at 1 w, which were enriched in the MAPK signaling pathway. (f) 55 DEGs were screened out between DEG2 and DEGs at 1 d, which were enriched in leukocyte chemotaxis, inflammatory response, and cell killing. (g) 71 DEGs were screened out between DEG2 and DEGs at 1 w, which were mainly enriched in leukocyte chemotaxis and regulation of cell adhesion.

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