MicroRNA-181b Serves as a Circulating Biomarker and Regulates Inflammation in Heart Failure

<div>Effects of miR-181b on the expression of proinflammatory cytokines in cultured neonatal cardiomyocytes. (a) Real-time PCR analysis of miR-181b expression in cultured neonatal cardiomyocytes treated with LPS for 3 hours. (b–d) Effects of miR-181b on the expressions of TNF-<i>α</i>, IL-1<i>β</i>, and IL-6 in cultured neonatal cardiomyocytes treated with LPS. 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318C104 327 142 338 184 338C294 338 347 275 347 187C347 112 305 39 221 39C160 39 119 71 97 89C88 97 80 96 71 90C59 80 50 67 49 57C48 45 52 36 66 23C80 9 123 -12 169 -12C221 -11 288 15 342 59C403 109 431 165 431 225C431 308 366 395 238 395C212 395 165 379 127 364L153 550Z"></path></g></svg> compared with the control group, <sup>#</sup><svg height="9.2729pt" id="M84" style="vertical-align:-0.6370001pt" version="1.1" viewbox="-0.0498162 -8.6359 44.8393 9.2729" width="44.8393pt" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink"><g transform="matrix(.013,0,0,-0.013,0,0)"><path d="M600 480C600 590 528 650 384 650H143L137 622C222 614 225 607 210 531L130 127C113 41 106 36 23 28L17 0H294L300 28C204 36 195 42 212 127L243 284L314 263C327 263 339 263 352 264C465 271 600 337 600 480ZM508 481C508 351 402 304 329 304C289 304 265 311 250 317L295 559C302 594 310 606 323 611C335 616 350 619 367 619C455 619 508 573 508 481Z"></path></g><g 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431 225C431 308 366 395 238 395C212 395 165 379 127 364L153 550Z"></path></g></svg> compared with the LPS+miRNA inhibitor negative control.</div>

Disease Markers

fig4

Figure 4

Figure 4: MicroRNA-181b Serves as a Circulating Biomarker and Regulates Inflammation in Heart Failure 